74405-46-2

Basic information

• Product Name: IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID
• Synonyms: IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID;5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-O-SUCCINIC ACID;5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-(hydrogen butanedioate);n2-isobutyryl-5'-o-(4,4'-dimethoxytrityl)-2'-deoxyguanosine 3'-o-succinic acid;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-hydrogen butanedioate;Succinic acid 1-[N-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-3'-guanosyl] ester;2'-Deoxy-5'-O-DMT-N2-isobutyrylguanosine 3'-O-succinate;N2-Isobutyryl-5'-O-(4,4'-diMethoxytrityl)-2'-deoxyguanosine 3'-O-succinic acid
• CAS NO: 74405-46-2
• Molecular Formula: C₃₉H₄₁N₅O₁₀
• Molecular Weight: 739.77
• EINECS: 277-854-8
• Product Categories: Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides
• Mol File: 74405-46-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.37g/cm³
• Refractive Index: 1.641
• Storage Temp.: −20°C
• CAS DataBase Reference: IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID(74405-46-2)
• EPA Substance Registry System: IBU-DMT-DEOXYGUANOSINE SUCCINIC ACID(74405-46-2)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 22-26-36-45
• WGK Germany: 3
• Hazardous Substances Data: 74405-46-2(Hazardous Substances Data)

Usage

Uses

2''-Deoxy-5''-O-DMT-N2-isobutyrylguanosine 3''-O-succinate is a nucleoside used in the synthetic preparation of DNA fragments, such as small-molecule/DNA hybrids via amide coupling. 2''-Deoxy-5''-O-DMT-N2-isobutyrylguanosine 3''-O-succinate can also be used as a solid phase support for oligonucleotide synthesis.

InChI:InChI=1/C39H41N5O10/c1-23(2)36(48)42-38-41-35-34(37(49)43-38)40-22-44(35)31-20-29(54-33(47)19-18-32(45)46)30(53-31)21-52-39(24-8-6-5-7-9-24,25-10-14-27(50-3)15-11-25)26-12-16-28(51-4)17-13-26/h5-17,22-23,29-31H,18-21H2,1-4H3,(H,45,46)(H2,41,42,43,48,49)

Upstream product

• 108-30-5 succinic acid anhydride 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 

Relevant articles and documents

Stereospecific grignard activated coupling of a deoxynucleoside: Methylphosphonate on a polyethylene glycol support

Stereospecific synthesis of Rp and Sp methylphosphonate diastereoisomers of d(ApG) was carried out on a polymeric support, polyethylene glycol (PEG), by the Grignard reagent solution route described by Stec. The coupling yield on PEG was higher than that observed in solution, and precipitation of the PEG at each step allowed easy separation of oligomer product from soluble reactants at each step.