Stereospecific grignard activated coupling of a deoxynucleoside: Methylphosphonate on a polyethylene glycol support

Article abstract of DOI:10.1016/0040-4039(94)88502-8

Stereospecific synthesis of Rp and Sp methylphosphonate diastereoisomers of d(ApG) was carried out on a polymeric support, polyethylene glycol (PEG), by the Grignard reagent solution route described by Stec. The coupling yield on PEG was higher than that observed in solution, and precipitation of the PEG at each step allowed easy separation of oligomer product from soluble reactants at each step.