74410-97-2

Basic information

• Product Name: 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester
• Synonyms: 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester;methyl 3-methylisothiazole-4-carboxylate, 4-(Carbomethoxy)-3-methyl-1,2-thiazole, 4-methoxycarbonyl-3-methylisothiazole, 3-methyl-isothiazole-4-carboxylic acid methyl ester, 3-Methyl-isothiazol-carbonsaeure-(4)-methylester
• CAS NO: 74410-97-2
• Molecular Formula: C6H7NO2S
• Molecular Weight: 157.19028
• Mol File: 74410-97-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester(74410-97-2)
• EPA Substance Registry System: 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester(74410-97-2)

Safety Data

• Hazardous Substances Data: 74410-97-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester is used as a chemical intermediate for the synthesis of substituted fused pyrimidinamines. These pyrimidinamines act as PI3 kinase modulators, which are important in the development of cancer treatment therapies.
In the context of cancer treatment, 4-Isothiazolecarboxylic acid, 3-Methyl-, Methyl ester plays a crucial role in the preparation of compounds that can modulate the activity of PI3 kinase. This enzyme is a key component in cellular signaling pathways, and its dysregulation has been implicated in various types of cancer. By targeting PI3 kinase, these pyrimidinamines can potentially inhibit tumor growth and proliferation, making them valuable in the development of novel cancer therapies.

Upstream product

• 3880-02-2 (Ethylimino)sulfur Difluoride 
• 922-67-8 propynoic acid methyl ester 
• 1420625-84-8 methyl 3-amino-2-thioformylbut-2-enoate 
• 14205-39-1 methyl 3-aminocrotonate 
• 92498-49-2 1-(3-methyl-isothiazole-4-carbonyl)-1,2-dihydro-quinoline-2-carbonitrile 
• 15903-66-9 3-methyl-isothiazole-4-carboxylic acid 
• 17265-59-7 3-methyl-isothiazole-4-carbaldehyde 
• 14205-39-1 methyl (E)-3-aminocrotonate 
• 124413-10-1 methyl 3-amino-2-thioformylisocrotonate 
• 67-56-1 methanol 
• 10284-34-1 3-methyl-isothiazole-4-carbonyl chloride 

Downstream Products

• 89179-69-1 3-methyl-isothiazole-4-carboxylic acid hydrazide 
• 15903-66-9 3-methyl-isothiazole-4-carboxylic acid 
• 1383546-18-6 5-iodo-3-methylisothiazole-4-carboxylic acid 
• 1420830-29-0 pinacol 
• 1420830-30-3 C₁₄H₁₀N₂O₂S 
• 1420626-70-5 C₁₅H₁₅N₃OS 
• 1420830-32-5 C₁₅H₁₃N₅OS 
• 1420830-31-4 C₁₅H₁₄N₂O₂S 
• 1435484-06-2 C₁₆H₁₄N₂O₃S 
• 1420830-27-8 C₁₆H₁₆N₂O₄S 
• 1420830-26-7 C₁₇H₁₈N₂O₃S 
• 1420830-25-6 C₁₃H₁₂N₂OS 
• 1420830-24-5 C₁₁H₉IN₂OS 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions of formulae (I), (XI) and (XII) as PI3 kinase modulators and their use in the treatment of diseases such as cancer.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Synthesis of 2-llkoxycarbonyl enamino thioaldehydes and selenaldehydes (as Pentacarbonyltungsten(0) Complexes). Improved synthesis of simple and 2-cyano enamino thioaldehydes and some chemical reactions of these compounds

A series of stable 2-alkoxycarbonyl enamino thioaldehydes (2a-g) were synthesized by solvolysis of the Vilsmeier salts (1) with aqueous or methanolic sodium hydrogen sulphide. Three 2-alkoxycarbonyl enamino selenaldehydes were obtained as the pentacarbonyltungsten(o) complexes (7a-c). The 2-cyano and simple enamino thioaldehydes (3a-m) and (6a-j) (including some new homologues obtained by an improved synthetic method) are described. Some reactions of 2-cyano and 2-alkoxycarbonyl enamino thioaldehydes were examined e.g. oxidation with MCPBA to give the isothiazoles (8). The symmetrically tetrasubstituted pyridines (9) were produced by bimolecular cyclisation under acidic conditions: hydrolysis in acidic 95% aq. EtOH gave the enamino aldehydes (11) and aroylacetonitriles (12) together with (9). The imines (13) were formed in good yield on reaction with primary amines.

Some 1,3-Dipolar Cycloaddition Reactions of Nitrile N-Sulfides with Acetylenes and Olefins

The generation of nitrile N-sulfides from iminosulfur difluorides is general.Trifluoroacetonitrile N-sulfide was allowed to react with some acetylenes and olefins.For example, N-phenylmaleimide gave N-phenyl-3-trifluoromethyl-1,2-thiazoline-4,5-carboximid