744209-08-3

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 75000-24-7 2-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 21091-61-2 2-(4-phenyl-piperazin-1-yl)-ethylamine 
• 4133-34-0 7-methoxyl-2-tetralone 

Downstream Products

• 477788-86-6 N-(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-[2-(4-phenyl-piperazin-1-yl)-ethyl]-propionamide 
• 477788-85-5 (7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-[2-(4-phenyl-piperazin-1-yl)-ethyl]-prop-2-ynyl-amine 
• 744209-06-1 (+)-2-methoxy-N-(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-2-phenyl-N-[2-(4-phenyl-piperazin-1-yl)-ethyl]-acetamide 
• 744209-07-2 (-)-2-methoxy-N-(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-2-phenyl-N-[2-(4-phenyl-piperazin-1-yl)-ethyl]-acetamide 
• 1003565-61-4 N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-N-[2-(4-phenylpiperazin-1-yl)ethyl]-2-(thiophen-2-yl)acetamine 
• 477788-87-7 (7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amine 

Relevant academic research and scientific papers

Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2- ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration

This paper describes an extended structure-activity relationships study of aminotetralin-piperazine-based hybrid molecules developed earlier for dopamine D2/D3 receptors. Various analogues as positional isomers have been developed where location of the ph

Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors

In a recent preliminary communication we described the development of a series of hybrid molecules for the dopamine D2 and D3 receptor subtypes. The design of these compounds was based on combining pharmacophoric elements of aminotetralin and piperazine m

Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity

Hybrid compounds containing in aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially high relative binding efficiencies between D3 and D2 dopaminergic receptor subtypes.

A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: Binding activity at D2 and D3 receptors

A series of 7-hydroxy-2-[N-alkyl-(N-(4-phenylpiperazine)-alkyl)amino]tetralins was developed based on a novel hybrid approach that combined 2-aminotetralin and arylpiperazine pharmacophoric moieties. Our preliminary study revealed that a four-methylene bu