744253-35-8Relevant academic research and scientific papers
INHIBITOR OF BINDING OF S1P1
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Page/Page column 12-13, (2010/05/13)
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: (wherein Y1 represents a nitrogen atom or a group represented by CRA, Y2 represents a nitrogen atom or a group represented by CRB/s
Synthesis of benzoylpyrimidines as antagonists of the corticotropin- releasing factor-1 receptor
Webb, Thomas R.,Moran, Terry,Huang, Charles Q.,McCarthy, James R.,Grigoriadis, Dimitri E.,Chen, Chen
, p. 3869 - 3873 (2007/10/03)
A series of benzoylpyrimidines derived from the anilinepyrimidine CRF 1 antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (Ki=15nM) exhibited high binding affinities at the human CRF 1 receptor.
