74432-58-9

Upstream product

• 836-43-1 4-benzyloxybenzyl alcohol 
• 67-64-1 acetone 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 
• 100-44-7 benzyl chloride 

Downstream Products

• 93822-20-9 dl-1-methyl-3-(4-benzyloxyphenyl)propylamine 
• 1020073-90-8 3,4-dibenzyloxy-N-[3-(4-benzyloxy)-1-methyl-n-propyl]-β-phenylethylamine hydrochloride 
• 5471-51-2 4-(4-hydroxyphenyl)-2-oxobutane 
• 1276197-17-1 ractopamine hydrochloride-D₆ 
• 32492-74-3 myricanone 
• 33606-81-4 (-)-aR-11R-myricanol 
• 181228-75-1 Myricanol 
• 68510-47-4 (+/-)-myricanol 
• 1426838-85-8 1-(4-(benzyloxy)phenyl)-7-(3-bromo-5-methoxyphenyl)-5-hydroxyheptan-3-one 

Relevant academic research and scientific papers

Oxidation of secondary alcohols using solid-supported hypervalent iodine catalysts

It is shown how secondary alcohols are oxidized to provide the corresponding ketones by use of Oxone and solid-supported hypervalent iodine catalysts. Under experimentally simple conditions with acetonitrile at elevated temperatures, excellent conversions were achieved with low catalyst loadings (0.2-5 mol%) when employing the conjugates 5 and 6 derived from IBX and IBS. The catalysts are broadly applicable to a range of alcohol substrates. Of primary importance with respect to sustainability issues, the metal-free catalysts are easily removed from the reaction mixture through filtration, and they can be re-used in oxidation processes for multiple times, without loss of catalytic activity.

KETONES AND METHOD FOR MANUFACTURING ANALOG THEREOF

PROBLEM TO BE SOLVED: To provide a technique for efficiently producing ketones by using cellulose after extracting chitin and chitosan extracted from the crustacean or sucrose from the beet in order to effectively using wastes, such as a crustacean or a beat to prepare a solid catalyst. SOLUTION: A method for manufacturing 1-phenyl-3-ketones and an analog (a compound 3) comprises using at least one kind selected from a group consisting of cellulose, chitin and chitosan as a carrier and reacting benzyl alcohols (a compound 1) with ketones (a compound 2) in the presence of a solid catalyst obtained by supporting a group 8-10 transition metal and a base. The following chemical formula 1 is shown. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Simple Synthesis of Phytochemicals by Heterogeneous Pd- and Ir-Catalyzed Hydrogen-Borrowing C–C Bond Formation

Chitin-supported palladium and iridium catalysts (i.e., Pd/chitin, Ir/chitin) successfully promote the hydrogen borrowing C–C bond formation reaction to afford phytochemicals and aroma compounds in excellent yields.

Rational design, synthesis and structure-activity relationships of 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues as novel tyrosinase inhibitors

In continuing our program aimed to search for potent compounds as highly efficient tyrosinase inhibitors, here a series of novel 4-alkoxy- and 4-acyloxy-phenylethylenethiosemicarbazone analogues were designed, synthesized and their biological activities on mushroom tyrosinase were evaluated. Notably, most of compounds displayed remarkable tyrosinase inhibitory activities with IC50 value of lower than 1.0 μM. Furthermore, the structure-activity relationships (SARs) were discussed and the inhibition mechanism and the inhibitory kinetics of selected compounds 7k and 8d were also investigated. Taken together, these results suggested that such compounds could serve as the promising candidates for the treatment of tyrosinase-related disorders and further development of such compounds might be of great interest.

A PROCESS FOR THE PREPARATION OF 4-[2-[[3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]AMINO]ETHYL]-1,2-BENZENEDIOL

The present invention relates to a process for the preparation of 4-[2-[[3-(4-hydroxyphenyl)-1- rnethylpropyl]amino]ethyl]-1,2-benzenediol, a compound of formula (I), and its pharmaceutically acceptable salts. The compound of formula (I), commonly known as dobutamine, is used in therapy as a cardiotonic for treating cardiac insufficiency. The process for preparation of a compound of formula (I) or its pharmaceutically acceptable salts comprises subjecting 3,4-bis(arylmethyloxy)-N-[3-(4-arylmethyloxy)-1 -methylpropyl]-β- phenethyl amine, a compound of formula (V), wherein R is independently selected from hydrogen, (C1-C6)alkyl, O-(C1-C6)-alkyl, aryl, O-aryl, aralkyl, halogen and hydroxyl, to catalytic hydrogenolysis.