74457-53-7

Upstream product

• 88493-26-9 2,2-difluoro-1-(1-hydroxyethyl)-3-phenylcyclopropane 
• 64-19-7 acetic acid 
• 104-15-4 toluene-4-sulfonic acid 
• 82045-04-3 (rac)-(E)-2-acetoxy-4-phenylbut-3-ene 
• 1895-39-2 sodium chlorodifluoroacetate 

Downstream Products

• 343774-32-3 1-(2,2-Difluoro-3-phenyl-cyclopropyl)-ethanone 
• 88493-26-9 2,2-difluoro-1-(1-hydroxyethyl)-3-phenylcyclopropane 
• 82045-07-6 methyl 2,2-difluoro-3-phenylcyclopropyl ketone 

Relevant academic research and scientific papers

Studies on Organic Fluorine Compounds. XL. Ring-Opening Reactions of gem-Difluorocyclopropyl Carbinols

Three types of ring-opening reactions of gem-difluorocyclopropyl carbinols are described; 1) reaction wih hydrobromic acid, 2) reaction with acetic acid in the presence of p-toluenesulfonic acid, and 3) rearrangement through a mesylate.Ring-opening reacti

Studies on Organic Fluorine Compounds. 38. Ring-Opening Reactions of gem-Difluorocyclopropyl Ketones with Nucleophiles

Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring-opening reaction of 3a,c,d having a hydrogen substituent at C1 adjacent to the carbonyl group with a methanolate anion gave carboxylic acid derivatives derived from C1-C2 bond scission (between the carbon atom with an acyl group and the carbon atom with fluorine substituents).On the other hand, reaction of 3a-c with a thiolate anion resulted in the C1-C3 bond cleavage (carbon-carbon bond opposite to the difluoromethylene group).

RING OPENING REACTION OF gem-DIFLUOROCYCLOPROPYL KETONES WITH NUCLEOPHILES

Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring opening reactions of 3a, c and d with a methanolate and a thiolate anion took entirely different courses of bond scission of the cyclopropane ring.