82045-07-6

Upstream product

• 1429215-47-3 methyl 2,2-difluoro-3-phenylcyclopropenyl ketone 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 74457-53-7 1-(1-acetoxyethyl)-2,2-difluoro-3-phenylcyclopropane 
• 82045-04-3 (rac)-(E)-2-acetoxy-4-phenylbut-3-ene 
• 88493-26-9 2,2-difluoro-1-(1-hydroxyethyl)-3-phenylcyclopropane 

Downstream Products

• 82045-15-6 1-[2-Phenyl-4H-benzo[1,4]thiazin-(3Z)-ylidene]-propan-2-one 
• 74457-46-8 1-phenyl-1,2-bis(phenylthio)pent-1-en-4-one 
• 82109-84-0 1-phenyl-1,2-bis(phenylthio)pent-2-en-4-one 
• 74457-44-6 methyl 4-keto-2-phenylpentanoate 

Relevant academic research and scientific papers

Cis-selective preparation of 2,2-difluorocyclopropyl ketones via non-metal hydride reduction of 2,2-difluorocyclopropenyl ketones

Diastereoselective reduction of gem-difluorocyclopropenyl ketones was accomplished by their Br?nsted acid catalyzed reactions with the non-metal based hydride transfer reagent, Hantzsch ester (diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate) (H

Studies on Organic Fluorine Compounds. 38. Ring-Opening Reactions of gem-Difluorocyclopropyl Ketones with Nucleophiles

Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring-opening reaction of 3a,c,d having a hydrogen substituent at C1 adjacent to the carbonyl group with a methanolate anion gave carboxylic acid derivatives derived from C1-C2 bond scission (between the carbon atom with an acyl group and the carbon atom with fluorine substituents).On the other hand, reaction of 3a-c with a thiolate anion resulted in the C1-C3 bond cleavage (carbon-carbon bond opposite to the difluoromethylene group).