74461-29-3

Upstream product

• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 97783-00-1 N,N',N-tris(p-toluenesulfonyl)-3,6,9-triazaundecane-1,11-di-p-toluenesulfonate 
• 74461-30-6 O¹,O¹¹-dimesyl-N³,N⁶,N⁹-tritosyl-3,6,9-triaza-1,11-undecanediol 
• 152488-76-1 26-phenyl-10,13,16-tritosyl-8,9,11,12,14,15,17,18-octahydro-26H-10,13,16-triaza-7,19-dioxadinaphtho<2,1-n,1',2'-q>cyclooctadecene 
• 164913-22-8 N¹-benzyl-N⁴,N⁷,N¹⁰,N¹³,N¹⁶-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 593284-46-9 1-(N-tosyl-2-aminoethyl)-4,7,10,13,16-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 593284-42-5 1-benzoyl-4,7,10,13,16-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 
• 164913-36-4 N¹,N⁴,N⁷,N¹⁰,N¹³-pentatosyl-1,4,7,10,13,16-hexaazacyclooctadecane 

Relevant academic research and scientific papers

Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm

A practical and reproducible route for the preparation of 1,4,7,10,13,16,19-heptaazacyclohenicosane (1), 1,4,7,10,13,16-hexaazacyclooctadecane (2), and 1,4,7,10,13,17-hexaazacycloicosane (3) bearing a single N-(2-amino-ethyl) pendant arm has been develope

Multi-layer macromonocyclic polyamines. I. Molecular design and synthesis of component monocyclic precursors

We designed 'multi-layer macromonocyclic polyamines' which might be appropriate polymorphismic molecular scaffolds as host-molecules in ionic or molecular interaction with small or large guest ions or molecules. In polymorphismic molecules, several macromonocyclic polyamines with the same and/or different ring sizes and nitrogen contents are connected to each other by alkylene spacers with various length of the chain. Actual target molecules are characterized by possessing methylene chain arrays of natural polyamines, and we have synthesized from simple starting materials fourteen component macromonocycles with various sizes, 12- to 34-membered rings containing three to eight nitrogen atoms, as essential building blocks required for construction of multi-layer molecules. Our method of synthesis was shown to be very efficient. In a final step, the N-protecting benzyl group was successfully removed by hydrogenation on 10%-Pd/C under 4 kg cm-2 H2 to give the cyclic amine precursors, which could be internal and terminal components in the architecture of the multi-layer molecules. The structures of synthesized compounds were characterized and confirmed by EA, 1H NMR, SIMS, and FAB(+) mass spectrometry.

Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: STR1 wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

Methods of preparing manganese complexes of nitrogen-containing macrocyclic ligands

The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: STR1 wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.

Two Series of Aza Macrocycles containing the Phenyldinaphthomethane Subunit (a three bladed propeller); Crystal Structures and Dynamic NMR Spectroscopy

Two new series of azapropeller crowns have been synthesised and investigated.The aza-propeller crowns 7,10-ditosylaza-1,4,13,16-tetraoxacyclooctadecane, (9a) and 4,7,10-tritosylaza-1,13-dioxacyclopentadecane, (11) have been shown by X-ray structure determ