74492-03-8

Basic information

• Product Name: (S)-(+)-2-N,N-dimethylamino-3-phenyl-1-propylchloride hydrochloride
• Synonyms: (S)-(+)-2-N,N-dimethylamino-3-phenyl-1-propylchloride hydrochloride
• CAS NO: 74492-03-8
• Molecular Weight: 234.169
• Mol File: 74492-03-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-(+)-2-N,N-dimethylamino-3-phenyl-1-propylchloride hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-2-N,N-dimethylamino-3-phenyl-1-propylchloride hydrochloride(74492-03-8)
• EPA Substance Registry System: (S)-(+)-2-N,N-dimethylamino-3-phenyl-1-propylchloride hydrochloride(74492-03-8)

Safety Data

• Hazardous Substances Data: 74492-03-8(Hazardous Substances Data)

Upstream product

• 27720-03-2 S-2-(Dimethylamino)-3-phenyl-1-propanol 
• 63-91-2 L-phenylalanine 
• 3182-95-4 L-Phenylalaninol 
• 17469-89-5 (2S)-2-(dimethylamino)-3-phenylpropanoic acid 
• 85711-08-6 (S)-2-(dimethylamino)-3-phenyl-1-propanol hydrochloride 

Downstream Products

• 130894-08-5 (+)-8-((2S)-2-dimethylamino-3-phenylpropyloxy)quinoline 
• 74492-07-2 diphenylphosphine 
• 77693-44-8 [(S)-1-Benzyl-2-(benzyl-phenyl-phosphanyl)-ethyl]-dimethyl-amine 
• 77693-42-6 Dimethyl-((S)-2-phenyl-1-phenylphosphanylmethyl-ethyl)-amine 

Relevant articles and documents

Stereoselective reactions. XIX. Asymmetric dihydroxylation of olefins by employing osmium tetroxide-chiral amine complexes

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ENANTIOSELECTIVE METAL-COMPLEX CATALYSIS. IV. DEPENDENCE OF THE CONFIGURATION OF THE PRODUCT ON CONFIGURATION OF THE METAL COMPLEX IN AN ASYMMETRIC CROSS-COUPLING REACTION

Rules relating the conformation of the catalytic complex and configuration of the reaction products are proposed for the cross-coupling reactions of alkyl (aryl) or sec-alkyl Grignard reagents and organozinc compounds with derivatives of olefins in the presence of nickel complexes containing chiral diphosphine or phosphine amine ligands.The rules were checked in the cross-coupling reactions of arylmagnesium bromides with crotyl alcohol and 1-(4-isobutylphenyl)ethylmagnesium bromide with vinyl bromide in the presence of NiCl2/S-Phephos (optical yields 29-83percent).

Chiral β-dimethylaminoalkylphosphines. Highly efficient ligands for a nickel complex catalyzed asymmetric grignard cross-coupling reaction

Chiral β-dimethylaminoalkylphosphines were prepared starting with amino acids, (S)-alanine, (S)-phenylalanine, (R)-phenylglycine, (S)-valine, and (R)-tert-leucine. The chiral phosphines were found to be highly efficient ligands for a nickel catalyzed asymmetric Grignard cross-coupling reaction (38～94% optical yield).