7450-62-6

Basic information

• Product Name: diethyl (4-methylbenzene-1,3-diyl)biscarbamate
• Synonyms: carbamic acid, N,N'-(4-methyl-1,3-phenylene)bis-, diethyl ester; Diethyl (4-methyl-1,3-phenylene)biscarbamate
• CAS NO: 7450-62-6
• Molecular Formula: C₁₃H₁₈N₂O₄
• Molecular Weight: 266.293
• Mol File: 7450-62-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 306.4°C at 760 mmHg
• Flash Point: 139.1°C
• Density: 1.223g/cm³
• Vapor Pressure: 0.000774mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: diethyl (4-methylbenzene-1,3-diyl)biscarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (4-methylbenzene-1,3-diyl)biscarbamate(7450-62-6)
• EPA Substance Registry System: diethyl (4-methylbenzene-1,3-diyl)biscarbamate(7450-62-6)

Safety Data

• Hazardous Substances Data: 7450-62-6(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 201230-82-2 carbon monoxide 
• 121-14-2 2,4-dinitrotoluene 
• 95-80-7 4-methylbenzene-1,3-diamine 
• 57-13-6 urea 
• 51-79-6 urethane 
• 584-84-9 2,4-Toluene diisocyanate 
• 541-41-3 chloroformic acid ethyl ester 
• 62881-00-9 (3-isocyanato-4-methyl-phenyl)-carbamic acid ethyl ester 
• 6935-99-5 2,4-bis(methoxycarbonylamino)toluene 
• 105-58-8 Diethyl carbonate 
• 7440-32-6 titanium 

Downstream Products

• 25635-03-4 1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea) 
• 10097-06-0 2,4-tolylene diurea 
• 64-17-5 ethanol 
• 584-84-9 2,4-Toluene diisocyanate 

Relevant articles and documents

Synthesis and antitussive activity of obtucarbamate A derivatives

Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1percent using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 °C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.

ONE-POT PRODUCTION OF CARBAMATES USING SOLID CATALYSTS

The invention relates to the production of carbamates in a single reactor (one-pot) using solid catalysts, involving the reaction between at least one nitro compound, an organic carbonate of formula (OR)(OR')C=O, a gas selected from hydrogen gas and a mixture of gases containing hydrogen and hydrogen precursor compounds, and a catalyst that has at least one metallic oxide and can also contain an element of groups 8, 9, 10 and 11 of the periodical table. The carbonates obtained can be transformed into their corresponding isocyanates.

Mild and high-yielding molybdenum(VI) dichloride dioxide-catalyzed formation of Mono-, Di-, Tri-, and tetracarbamates from alcohols and aromatic or aliphatic isocyanates

Both molybdenum(VI) dichloride dioxide (MoO2Cl2) and its dimethylformamide (DMF) complex catalyze the addition of alcohols to isocyanates giving carbamates. Most additions proceeded to completion at room temperature within 20 min using as little as 0.1 mol% of the catalyst when working on a 1-mmol scale or just 100 ppm working on a 20-mmol scale. Sterically encumbered substrates reacted to completion when 1 mol% of the catalyst was employed. Diols, triols, and tetraols reacted with monoisocyanates likewise, as did monofunctional alcohols and diisocyanates. These pairings furnished di-, tri-, tetra-, and dicarbamates, respectively. Reactants, which were poorly soluble in CH2Cl2 at room temperature required elevating the temperature and possibly choosing a higher-boiling solvent (ClCH 2CH2Cl, DMF) as well. Additions of diols to diisocyanates were feasible, too, giving polycarbamates as we presume. Copyright