25635-03-4

Basic information

• Product Name: 1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea)
• Synonyms: 1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea)
• CAS NO: 25635-03-4
• Molecular Weight: 264.327
• Mol File: 25635-03-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea)(25635-03-4)
• EPA Substance Registry System: 1,1'-(4-methyl-1,3-phenylene)bis(3-ethylurea)(25635-03-4)

Safety Data

• Hazardous Substances Data: 25635-03-4(Hazardous Substances Data)

Usage

Type of compound

Urea derivative

Structure

Contains a 4-methyl-1,3-phenylene backbone with two ethylurea substituents

Physical appearance

White or off-white crystalline powder

Solubility

Insoluble in water, soluble in organic solvents

Industrial applications

a. Corrosion inhibitor in metalworking fluids
b. Stabilizer in the production of pesticides

Potential pharmaceutical applications

a. Antitumor properties
b. Antiviral properties

Usage

Widely used in pharmaceuticals and agricultural products production

Upstream product

• 10097-06-0 2,4-tolylene diurea 
• 75-03-6 ethyl iodide 
• 7450-62-6 2,4-bis-(ethoxycarbonylamino)toluene 
• 75-04-7 ethylamine 
• 584-84-9 2,4-Toluene diisocyanate 
• 6935-99-5 2,4-bis(methoxycarbonylamino)toluene 

Relevant articles and documents

Synthesis and antitussive activity of obtucarbamate A derivatives

Obtucarbamate A was purified from Disporum cantoniense with good antitussive property. In present work, a series of obtucarbamate A derivatives were designed and synthesized from obtucarbamate A by microwave method, and their antitussive activity were evaluated. The results showed that the toluene diisocyanate was obtained with a yield of 95.1percent using a simple method, 1-methyl-2-pyrrolidinone as solvent, temperature of 190 °C, microwave irradiation at 60 W power for 30 min. All compounds have good antitussive activity, and small steric hindrance unsaturated groups of ester chains and amino groups favor activity. It is the first reported of obtucarbamate A derivatives used as antitussive, and the results provide a basis for the application of obtucarbamate derivatives as new antitussive.