745014-33-9

Upstream product

• 31327-97-6 acridine-4-carboxylic acid 
• 745014-30-6 (2S)-N-[4-(3-aminopropoxy)-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 24782-64-7 9-Oxoacridan-4-carboxylic acid 
• 127810-77-9 (2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 
• 118-92-3 anthranilic acid 
• 40961-10-2 9,10-dihydro-acridine-4-carboxylic acid 
• 579-92-0 Vanadox 
• 140647-02-5 (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 118-91-2 ortho-chlorobenzoic acid 
• 745014-29-3 (2S)-N-[4-(N-t-butoxycarbonyl)aminopropoxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Downstream Products

• 745014-34-0 (2S)-N-{4-[3'-(4-acridi-nylcarboxamido)-propyl]-oxy-5-methoxy-2-aminobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Relevant academic research and scientific papers

C-8 LINKED PYRROLO[2,1-c][1,4]BENZODIAZEPINE-ACRIDONE/ACRIDINE HYBRIDS

The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine of the formula given below wherein R is Hor OH and n is 2-3 ( formula (I) and (II) useful as anti-tumour agents and a process for the preparation thereof.

C8 - linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids

The present invention provides novel pyrrolo-[2,1-c][1,4]benzodiazepine hybrids useful as anti-tumour agents and a process for the preparation thereof.

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.