745048-13-9

Upstream product

• 146462-59-1 1-(methylsulfonyl)-10-(triphenylcarbinyl)-1,4,7,10-tetraoxadecane 
• 76-84-6 triphenylmethyl alcohol 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 133699-09-9 10,10,10-triphenyl-3,6,9-trioxadecan-1-ol 
• 76-83-5 trityl chloride 

Downstream Products

• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 198063-13-7 1-amino-8-trityloxy-3,6-dioxaoctane 
• 883992-09-4 8-trityloxy-1-{3-[1-(p-chlorobenzoyl)-5-methoxy-2-methylindol-acetamido]}-3,6-dioxaoctane 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

Synthesis and stability of two indomethacin prodrugs

The purpose of this study was to synthesize and study the in vitro enzymatic and non-enzymatic hydrolysis of indomethacin-TEG ester and amide prodrugs. It was found that the ester conjugate 10 was comparatively stable between pH 3 and 6 (half-life >90 h),

Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor

Following a recent description of fluorescence resonance energy transfer between enhanced green fluorescent protein (EGFP)-fused human muscarinic M1 receptors and Bodipy-labeled pirenzepine, we synthesized seven fluorescent derivatives of this antagonist in order to further characterize ligand-receptor interactions. These compounds carry Bodipy [558/568], Rhodamine Red-X [560/580], or Fluorolink Cy3 [550/570] fluorophores connected to pirenzepine through various linkers. All molecules reversibly bind with high affinity to M1 receptors (radioligand and energy transfer binding experiments) provided that the linker contains more than six atoms. The energy transfer efficiency exhibits modest variations among ligands, indicating that the distance separating EGFP from the fluorophores remains almost constant. This also supports the notion that the fluorophores may bind to the receptor protein. Kinetic analyses reveal that the dissociation of two Bodipy derivatives (10 or 12 atom long linkers) is sensitive to the presence of the allosteric modulator brucine, while that of all other molecules (15-24 atom long linkers) is not. The data favor the idea that these analogues might interact with both the acetylcholine and the brucine binding domains.