745052-96-4Relevant academic research and scientific papers
Development of an enantioselective hydrogenation based synthesis of a glucokinase activator
Magnus, Nicholas A.,Braden, Timothy M.,Buser, Jonas Y.,Debaillie, Amy C.,Heath, Perry C.,Ley, Christopher P.,Remacle, Jacob R.,Varie, David L.,Wilson, Thomas M.
, p. 830 - 835 (2012/08/27)
This article describes the development and optimization of chemical reactions and subsequent multikilogram preparation of the glucokinase activator (R)-1 to fund clinical evaluation as a potential therapeutic for type II diabetes. The major process developments presented here are a Wittig olefination isomerization based synthesis of an E-acrylic acid, an optimized enantioselective hydrogenation of the E-acrylic acid, and a challenging final amide coupling.
CRYSTALLINE (R)-2-(4-CYCLOPROPANESULPHONYL-PHENYL)-N-PYRAZIN-2-YL-3-(TETRAHYDROPYRAN-4-YL)-PROPIONAMIDE
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Page/Page column 4; 5, (2009/07/25)
Crystalline R-2-(4-cyclopropanesulfonyl-phenyl)-N-pyrazin-2-yl-3-(tetrahydropyran-4-yl)-propionamide and methods of its preparation and use are disclosed.
TRICYCLO SUBSTITUTED AMIDES
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Page/Page column 14-15, (2008/06/13)
Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
TRI(CYCLO) SUBSTITUTED AMIDE COMPOUNDS
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Page 31-33, (2008/06/13)
Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
