745060-01-9

Basic information

• Product Name: ethyl 3-(4-methoxyphenyl)-4-nitrobutanoate
• Synonyms: ethyl 3-(4-methoxyphenyl)-4-nitrobutanoate
• CAS NO: 745060-01-9
• Molecular Weight: 267.282
• Mol File: 745060-01-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4-methoxyphenyl)-4-nitrobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4-methoxyphenyl)-4-nitrobutanoate(745060-01-9)
• EPA Substance Registry System: ethyl 3-(4-methoxyphenyl)-4-nitrobutanoate(745060-01-9)

Safety Data

• Hazardous Substances Data: 745060-01-9(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 2033-24-1 cycl-isopropylidene malonate 
• 75-52-5 nitromethane 
• 64-17-5 ethanol 
• 24393-56-4 ethyl p-methoxycinnamate 

Downstream Products

• 1019648-68-0 bis(2,2,2-trichloroethyl)(4-(4-(4-methoxyphenyl)-2-oxopyrrolidin-1-yl)pyridin-2-yl)imidodicarbonate 
• 1019648-69-1 N-(4-(4-(4-methoxyphenyl)-2-oxopyrrolidin-1-yl)pyridin-2-yl)-N'-(pyridin-2-ylmethyl)urea 
• 103859-86-5 (-)-4-(4'-methoxy-phenyl)-2-pyrrolidone 

Relevant articles and documents

Asymmetric synthesis of piperidines using the nitro-Mannich reaction☆

A method for the synthesis of functionalized piperidines containing 3 contiguous stereocentres in the 2-,3- and 4- positions uses a diastereoselective nitro-Mannich to control stereochemistry. The nitro-Mannich reaction between a β-aryl/heteroaryl substituted nitroalkanes and glyoxylate imine provides β-nitro-amines with good selectivity (70:30 to >95:5) for the syn, anti-diastereoisomers. Reductive cyclisation with BF3.OEt2 and Et3SiH gave, after purification, stereochemically pure piperidines in 19–57% yield for ten examples with different 4-aryl/heteroaryl substituents.

GSK-3BETA INHIBITOR

For the purpose of providing a GSK-3β inhibitor containing a 2-aminopyridine compound or a salt thereof or a prodrug thereof useful as an agent for the prophylaxis or treatment of a GSK-3β-related pathology or disease, the present invention provides a GSK-3β inhibitor containing a compound represented by the formula (IA): wherein each symbol is as defined in the specification. or a salt thereof or a prodrug thereof.