745079-29-2

Upstream product

• 2150-45-0 methyl 2,6-dihydroxybenzoate 
• 745079-27-0 ethyl 4-((acetyloxy)methyl)-5-{3-((1E)-3-hydroxyprop-1-enyl)phenyl}isoxazole-3-carboxylate 
• 2411-83-8 methyl-2,3-dihydroxybenzoate 
• 745079-24-7 ethyl 4-(hydroxymethyl)-5-(3-iodophenyl)isoxazole-3-carboxylate 
• 745079-26-9 ethyl 4-((acetyloxy)methyl)-5-(3-iodophenyl)isoxazole-3-carboxylate 
• 745079-25-8 5-(3-iodo-phenyl)-isoxazole-3,4-dicarboxylic acid 3-ethyl ester 
• 745079-23-6 4-tert-butyl 3-ethyl 5-(3-iodophenyl)isoxazole-3,4-dicarboxylate 
• 745079-22-5 tert-butyl 3-(3-iodophenyl)-3-oxopropanoate 

Relevant academic research and scientific papers

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (>20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells. Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (>20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells.

Protein-tyrosine phosphatase inhibitors and uses thereof

The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.