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CAS

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745079-27-0

3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-[3-[(1E)-3-hydroxy-1-propenyl]phenyl]-, ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 745079-27-0 Structure

  • Basic information

    1. Product Name: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-[3-[(1E)-3-hydroxy-1-propenyl]phenyl]-, ethyl ester
    2. Synonyms:
    3. CAS NO:745079-27-0
    4. Molecular Formula: C18H19NO6
    5. Molecular Weight: 345.352
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 745079-27-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-[3-[(1E)-3-hydroxy-1-propenyl]phenyl]-, ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-[3-[(1E)-3-hydroxy-1-propenyl]phenyl]-, ethyl ester(745079-27-0)
    11. EPA Substance Registry System: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-[3-[(1E)-3-hydroxy-1-propenyl]phenyl]-, ethyl ester(745079-27-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 745079-27-0(Hazardous Substances Data)

745079-27-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 745079-27-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,5,0,7 and 9 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 745079-27:
(8*7)+(7*4)+(6*5)+(5*0)+(4*7)+(3*9)+(2*2)+(1*7)=180
180 % 10 = 0
So 745079-27-0 is a valid CAS Registry Number.

745079-27-0Relevant articles and documents

Protein-tyrosine phosphatase inhibitors and uses thereof

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Page 27, (2010/02/09)

The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Zhao, Hongyu,Liu, Gang,Xin, Zhili,Serby, Michael D.,Pei, Zhonghua,Szczepankiewicz, Bruce G.,Hajduk, Philip J.,Abad-Zapatero, Cele,Hutchins, Charles W.,Lubben, Thomas H.,Ballaron, Stephen J.,Haasch, Deanna L.,Kaszubska, Wiweka,Rondinone, Cristina M.,Trevillyan, James M.,Jirousek, Michael R.

, p. 5543 - 5546 (2007/10/03)

Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (>20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells. Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (>20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells.

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