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745079-26-9

3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-(3-iodophenyl)-, ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 745079-26-9 Structure

  • Basic information

    1. Product Name: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-(3-iodophenyl)-, ethyl ester
    2. Synonyms:
    3. CAS NO:745079-26-9
    4. Molecular Formula: C15H14INO5
    5. Molecular Weight: 415.184
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 745079-26-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-(3-iodophenyl)-, ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-(3-iodophenyl)-, ethyl ester(745079-26-9)
    11. EPA Substance Registry System: 3-Isoxazolecarboxylic acid, 4-[(acetyloxy)methyl]-5-(3-iodophenyl)-, ethyl ester(745079-26-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 745079-26-9(Hazardous Substances Data)

745079-26-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 745079-26-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,5,0,7 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 745079-26:
(8*7)+(7*4)+(6*5)+(5*0)+(4*7)+(3*9)+(2*2)+(1*6)=179
179 % 10 = 9
So 745079-26-9 is a valid CAS Registry Number.

745079-26-9Relevant articles and documents

Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors

Zhao, Hongyu,Liu, Gang,Xin, Zhili,Serby, Michael D.,Pei, Zhonghua,Szczepankiewicz, Bruce G.,Hajduk, Philip J.,Abad-Zapatero, Cele,Hutchins, Charles W.,Lubben, Thomas H.,Ballaron, Stephen J.,Haasch, Deanna L.,Kaszubska, Wiweka,Rondinone, Cristina M.,Trevillyan, James M.,Jirousek, Michael R.

, p. 5543 - 5546 (2007/10/03)

Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (>20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells. Guided by X-ray crystallography, we have extended the structure-activity relationship (SAR) study on an isoxazole carboxylic acid-based PTP1B inhibitor (1) and more potent and equally selective (>20-fold selectivity over the highly homologous T-cell PTPase, TCPTP) PTP1B inhibitors were identified. Inhibitor 7 demonstrated good cellular activity against PTP1B in COS 7 cells.

Protein-tyrosine phosphatase inhibitors and uses thereof

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Page 27, (2010/02/09)

The present invention is directed to compounds of formula (I), or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.

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