82599-15-3

Upstream product

• 82599-08-4 {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol 
• 89874-07-7 (3R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-3,4,4-trimethoxy-2-(2-phenylsulfanyl-ethoxy)-tetrahydro-pyran 
• 82598-98-9 Acetic acid (E)-(2R,5S,6R)-7-benzenesulfonyl-5-(tert-butyl-dimethyl-silanyloxy)-2,3,3-trimethoxy-6,8-dimethyl-undec-9-enyl ester 
• 82599-07-3 (2E,9E,11E)-(4S,5S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-13-(4-chloro-3-methoxy-5-methylamino-phenyl)-7,7,8-trimethoxy-2,4,12-trimethyl-trideca-2,9,11-trien-1-ol 
• 82598-96-7 (3R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-benzenesulfonyl-ethoxy)-3,4,4-trimethoxy-tetrahydro-pyran 
• 82598-94-5 (2S,3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-3-methoxy-4-(4-methoxy-benzyloxy)-2-(2-methoxy-ethoxy)-tetrahydro-pyran 
• 82599-05-1 {5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7,13,13-pentamethoxy-2,10,12-trimethyl-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester 
• 82599-03-9 {(E)-4-[4-Chloro-3-methoxy-5-(methoxycarbonyl-methyl-amino)-phenyl]-3-methyl-but-2-enyl}-triphenyl-phosphonium; bromide 
• 77943-80-7 {(Z)-1-Benzenesulfonyl-2-[(2S,6S)-6-(2-methoxy-ethoxy)-3,6-dihydro-2H-pyran-2-yl]-vinyl}-trimethyl-silane 
• 77943-81-8 {(Z)-1-Benzenesulfonyl-2-[(1R,2R,4R,6R)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]hept-4-yl]-vinyl}-trimethyl-silane 
• 77890-89-2 {(Z)-2-[6-(2-Methoxy-ethoxy)-5-phenylselanyl-tetrahydro-pyran-2-yl]-1-phenylsulfanyl-vinyl}-trimethyl-silane 
• 82599-06-2 {5-[(2E,4E,11E)-(6R,9S,10S)-9-(tert-Butyl-dimethyl-silanyloxy)-6,7,7-trimethoxy-2,10,12-trimethyl-13-oxo-trideca-2,4,11-trienyl]-2-chloro-3-methoxy-phenyl}-methyl-carbamic acid methyl ester 
• 82599-02-8 [5-(2-Benzenesulfonyl-2-methyl-pent-4-enyl)-2-chloro-3-methoxy-phenyl]-methyl-carbamic acid methyl ester 
• 82614-13-9 (3R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3,4,4-trimethoxy-tetrahydro-pyran 

Downstream Products

• 91365-95-6 (E)-3-{(2R,3R)-3-[(6E,8E)-(1R,2R,5S)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-acrylic acid methyl ester 
• 85621-22-3 (E)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-acrylic acid 
• 82599-16-4 (S)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-3-hydroxy-propionic acid ethyl ester 
• 82599-18-6 (R)-3-(tert-Butyl-dimethyl-silanyloxy)-3-{(2S,3R)-3-[(6E,8E)-(1R,2R,5S)-2-(tert-butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-propionic acid 
• 82599-17-5 (R)-3-(tert-Butyl-dimethyl-silanyloxy)-3-{(2S,3R)-3-[(6E,8E)-(1R,2R,5S)-2-(tert-butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-propionic acid ethyl ester 
• 57103-68-1 (+/-)-maytansinol 
• 85621-22-3 (E)-3-{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-acrylic acid 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF (+/-)-MAYSINE AND (+/-)-N-METHYLMAYSENINE

Maysine (1) and N-methylmaysenine (2), as congeners of the ansa-macrocyclic antitumor agent, maytansine, were synthesized from a common intermediate 3.