74530-92-0Relevant academic research and scientific papers
Pd-Catalyzed Allylic Isocyanation: Nucleophilic N-Terminus Substitution of Ambident Cyanide
Yurino, Taiga,Tani, Ryutaro,Ohkuma, Takeshi
, p. 4434 - 4440 (2019/05/10)
In the presence of catalytic amount of Pd(OAc)2, allylic phosphates reacted with trimethylsilyl cyanide (TMSCN) to afford the corresponding allylic isonitriles exclusively. No allylic nitriles, which are selectively obtained in the traditional
Isocyanide-based multicomponent reaction 'without' isocyanides
El Kaim, Laurent,Grimaud, Laurence,Schiltz, Aurélie
experimental part, p. 1401 - 1404 (2009/10/19)
We present here a one-pot, four-component sequence that affords Ugi-type adducts starting from simple benzyl or allyl bromides. The isocyanides are prepared in situ under alkylation of silver cyanide salts and the resulting mixture is directly used in a U
One-pot synthesis of oxazoles using isocyanide surrogates
Kaim, Laurent El,Grimaud, Laurence,Schiltz, Aurélie
experimental part, p. 5235 - 5237 (2009/12/06)
We wish to present herein a simple one-pot synthesis of 2,5-disubstituted oxazoles, starting from benzyl halides and acyl chlorides. The in situ formation of isocyanides, followed by the addition of an acyl chloride in the presence of a base leads to the
New Syntheses of Isomerically Pure Allyl and Propargyl Cyanides by Isocyanide-Cyanide Rearrangement
Wolber, Erwin K. A.,Schmittel, Michael,Ruechardt, Christoph
, p. 525 - 532 (2007/10/02)
A new route for the synthesis of isomerically pure allyl and propargyl cyanides has been developed.Allylic amines are synthesized from the corresponding alcohols by Mitsunobu or by Overman reaction.Formylation with formic acid derivatives provides N-substituted formamides, which are dehydrated to isocyanides. 1,2-Sigmatropic rearrangement by flash pyrolysis provides the isomerically pure allyl and propargyl cyanides. Key Words: Isocyanide-cyanide rearrangment / Cyanides, allyl- and propargyl-
