43219-52-9

Basic information

• Product Name: Formamide, N-(3-phenyl-2-propenyl)-, (E)-
• CAS NO: 43219-52-9
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Mol File: 43219-52-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Formamide, N-(3-phenyl-2-propenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-(3-phenyl-2-propenyl)-, (E)-(43219-52-9)
• EPA Substance Registry System: Formamide, N-(3-phenyl-2-propenyl)-, (E)-(43219-52-9)

Safety Data

• Hazardous Substances Data: 43219-52-9(Hazardous Substances Data)

Upstream product

• 1118-02-1 trimethylsilyl isocyanate 
• 124517-47-1 cinnamyl tert-butyl carbonate 
• 4335-60-8 (E)-cinnamylamine 
• 109-94-4 formic acid ethyl ester 
• 107-31-3 Methyl formate 
• 16250-37-6 N-allylformamide 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 64-18-6 formic acid 
• 17480-08-9 3-phenyl-2-propen-1-amine hydrochloride 
• 77287-34-4 formamide 
• 104-55-2 3-phenyl-propenal 
• 2687-12-9 cinnamyl chloride 

Downstream Products

• 16170-45-9 4-phenylbut-3-enenitrile 
• 4360-51-4 cinnamylamine 
• 1219505-17-5 N-(3-phenyl-2-propenyl)thioformamide 
• 74530-92-0 Cinnamylisocyanid 
• 43219-51-8 (E)-(3-isocyanoprop-1-en-1-yl)benzene 

Relevant articles and documents

Palladium-Catalyzed Synthesis of Allylic Ureas via an Isocyanate Intermediate

A palladium-catalyzed coupling of allylic carbonates with trimethylsilylisocyanate to provide allylic isocyanates is reported. Amines are added in a second step to yield allylic ureas in this one-pot procedure. Use of a bidentate phosphine ligand with a large bite angle was found to be important in this transformation. The scope of allylic carbonates has been examined, as well as amines compatible with these reaction conditions.

Rapid synthesis method of biomass-based amide

The invention discloses a rapid synthesis method of biomass-based amide, which comprises the steps: formamide is used as an amine source, formic acid is used as a hydrogen source, biomass aldehyde andketone is used as a raw material, the direct addition of formamide and aldehyde and ketone components and the reduction of formic acid is promoted to prepare the corresponding formamide derivative byrapidly heating under microwave-assisted heating and in the absence of a solvent and a catalyst; the formamide derivative is selectively converted to the corresponding primary amide by alcoholysis under the action of a base. The microwave assisted heating reaction system of the invention has higher catalytic efficiency than the corresponding oil bath system, greatly shortens the reaction time, remarkably improves the selectivity. The conversion rate of the biomass aldehyde or ketone compound is at least 99%, and the yield of the formamide derivative can reach 85 to 99%; the formamide can be synthesized by alcoholysis to obtain a primary amide with a yield of 92 to 99%.

Efficient isocyanide-less isocyanide-based multicomponent reactions

Isocyanides are the Jekyll and Hyde of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only in IMCR but in other areas of organic chemistry as well.