7454-50-4Relevant academic research and scientific papers
Synthesis of N -Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature
Ouyang, Banlai,Liu, Deming,Xia, Kejian,Zheng, Yanxia,Mei, Hongxin,Qiu, Guanyinsheng
supporting information, p. 111 - 115 (2017/12/27)
A copper-catalyzed Chan-Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N -arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.
Copper-catalyzed cross-coupling of chloramine salts and arylboronic acids in water: A green and practical route to N-arylsulfonamides
Ouyang, Banlai,Zheng, Yanxia,Liu, Yi,Liu, Fei,Yao, Juying,Peng, Yiyuan
, p. 3694 - 3698 (2018/09/14)
A green and practical method for the synthesis of N-arylsulfonamides from chloramine salts and arylboronic acids is herein developed. The reaction proceeds readily in the presence of 5 mol% of CuI and 2.5 equiv. K2CO3 in water at room temperature, generating a variety of N-arylsulfonamides in moderate to good yields with good functional group tolerance.
Synthesis and screening of in vitro antibacterial and enzyme inhibitory activity of N,N-disubstituted 4-chlorobenzenesulfonamides
Aziz-ur-Rehman,Nafeesa, Khadija,Abbasi, Muhammad Athar,Nadeem, Sohail,Khan, Khalid Mohammed,Ahmad, Irshad,Afzal, Saira
, p. 1096 - 1104 (2015/01/30)
Sulfonamide, pharmacologically important class of compounds, is of significant interest for scientists due to increased resistance in microbes against the existing drug constituents. So the aim of following research work was to synthesize new more effecti
Synthesis, structural analysis and pharmacological screening of chlorinated sulfonamides
Aziz-Ur-Rehman,Tahir, Saif-Ur-Rehman,Abbasi, Muhammad Athar,Rasool, Shahid,Siddiqa, Asia,Awais-Ur-Rehman,Muhammad, Ali,Sharif, Ahsan
, p. 9000 - 9004 (2013/11/19)
In present work, a facile and environmentally benign series of chlorinated sulfonamides was synthesized and screened against different enzymes. These were geared up by the coupling of 4-chlorobenzenesulfonyl chloride (1) with different substituted aromatic amines (2a-l) under dynamic pH control in aqueous media to form various chlorinated sulfonamides (3a-l). The synthesized chlorinated sulfonamides were spectrally characterized like 1H NMR, IR and EI-MS. The bioactivity of all the synthesized compounds were evaluated against urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX) enzymes and found to be having talented activity against butyrylcholinesterase enzyme.
