74542-54-4

Basic information

• Product Name: N,N-phenyl-p-toluenesulfonylbenzamide
• Synonyms: N,N-phenyl-p-toluenesulfonylbenzamide
• CAS NO: 74542-54-4
• Molecular Weight: 351.426
• Mol File: 74542-54-4.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: N,N-phenyl-p-toluenesulfonylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-phenyl-p-toluenesulfonylbenzamide(74542-54-4)
• EPA Substance Registry System: N,N-phenyl-p-toluenesulfonylbenzamide(74542-54-4)

Safety Data

• Hazardous Substances Data: 74542-54-4(Hazardous Substances Data)

Upstream product

• 68-34-8 phenyl toluenesulfonamide 
• 98-88-4 benzoyl chloride 
• 62-53-3 aniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 65-85-0 benzoic acid 
• 93-98-1 N-phenyl benzoyl amide 

Downstream Products

• 68-34-8 phenyl toluenesulfonamide 
• 65-85-0 benzoic acid 
• 611-94-9 4-Methoxybenzophenone 
• 345-83-5 4-fluorobenzophenone 
• 6158-54-9 methyl 4-Benzoylbenzoate 
• 1503-49-7 p-cyanobenzophenone 
• 53689-84-2 4-acetylbenzophenone 
• 642-29-5 1-benzoylnaphthalene 
• 131-58-8 2-Methylbenzophenone 
• 22679-42-1 2-ethylbenzophenone 
• 606-28-0 methyl o-benzoylbenzoate 
• 119-61-9 benzophenone 
• 134-84-9 4-Methylbenzophenone 
• 52392-64-0 (E)-3-(phenyl)acrylic acid butyl ester 

Relevant articles and documents

N-Aroylsulfonamide-Photofragmentation (ASAP)-A Versatile Route to Biaryls

The photochemical fragmentation of N-aroylsulfonamides 9 (ASAP) is a powerful method for the preparation of various biaryls. Compounds 9 are easily accessible in two steps from amines by treatment with arenesulfonyl chlorides and aroyl chlorides. Many of these compounds were prepared for the first time. The irradiation takes place in a previously developed continuous-flow reactor using inexpensive UVB or UVC fluorescent lamps. Isocyanates and sulphur dioxide are formed as the only by-products. The ASAP tolerates a variety of functional groups and is even suited for the preparation of phenylnaphthalenes and terphenyls. The ASAP mechanism was elucidated by interaction of photophysical and quantum chemical (DFT) methods and revealed a spirocyclic biradical as key intermediate.

A Strategy for Amide C-N Bond Activation with Ruthenium Catalyst: Selective Aromatic Acylation

A strategy for amide C-N bond activation with ruthenium catalyst is described for the first time. The in situ formed bis-cycloruthenated complexes were demonstrated to be the key active species with superior oxidative addition ability to an inert amide C-N bond. The direct C-H bond activation of 2-arylpyridines followed by the amide C-N bond activation took place in the presence of a ruthenium precatalyst to produce monoacylation products in moderate to good yields. Synthetically useful functional groups, such as halogen atoms (F and Cl), ester, acetyl, and vinyl, remained intact during tandem C-H/C-N bond activation reactions.

Transamidation for the Synthesis of Primary Amides at Room Temperature

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25 °C, the desired primary amide product is formed in good yield with good funcctional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.