74552-62-8

Usage

Structure

Contains a methoxy group and a phenyl group attached to the benzofuran ring

Uses

Used in various research applications and studied for potential pharmaceutical properties

Importance

Valuable tool for exploring potential biological activities and applications of benzofuran derivatives in drug discovery and development.

Upstream product

• 67-56-1 methanol 
• 74552-60-6 2-Hydroxy-2-(2-hydroxyphenyl)-1-phenylethanone 
• 74145-94-1 2-(2-Hydroxy-phenyl)-2-methoxy-1-phenyl-ethanone 
• 100-52-7 benzaldehyde 
• 1078-31-5 2-trimethylsilanyloxy-benzaldehyde 
• 31675-43-1 diethyl 1-phenyl-1-(trimethylsiloxy)methanephosphonate 

Relevant academic research and scientific papers

ortho-Oxygenative 1,2-Difunctionalization of Diarylalkynes under Merged Gold/Organophotoredox Relay Catalysis

Reported herein is an ortho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox catalysis to access highly functionalized 2-(2-hydroxyaryl)-2-alkoxy-1-arylethan-1-ones. Detailed mechanistic studies suggested a relay process, initiating with gold-catalyzed hydroalkoxylation of alkynes, to generate enol-ether followed by a key formal [4+2]-cycloaddition reaction. The successful application of the present methodology was also shown for the synthesis of benzofurans.

α-Heterosubstituted Phosphonate Carbanions. 11. Benzoins via an Acyl Anion Equivalent. Novel One-Pot Preparation of Benzofurans via Benzoins Using Hydriodic Acid

Diethyl 1-(trimethylsiloxy)-1-phenylmethanephosphonate carbanion 2 is introduced as a novel acyl anion equivalent.When 2 reacts with aldehydes or ketones, a 1,4 oxygen-oxygen silicon migration with subsequent loss of diethyl lithium phosphite is observed.An efficient method utilizing 2 for the preparation of otherwise difficultly obtainable substituted benzoins is presented.Also a novel one-pot method which offers a facile entry into the 2-phenylbenzofuran ring system from 2 via benzoin intermediates using hydriodic acid was developed.