74559-69-6Relevant academic research and scientific papers
Novel supramolecular palladium catalyst for the asymmetric reduction of imines in aqueous media
Da Silva, Wender A.,Rodrigues Jr., Manoel T.,Shankaraiah,Ferreira, Renan B.,Andrade, Carlos Kleber Z.,Pilli, Ronaldo A.,Santos, Leonardo S.
supporting information; experimental part, p. 3238 - 3241 (2010/02/28)
A novel approach to the asymmetric reduction of dihydro-β-carboline derivatives to the corresponding tetrahydro-β-carbolines is described based on the supramolecular lyophilized complex formed from β-cyclodextrin/ imines as an enzyme mimetic and palladium hydride as the reducing agent. The methodology allowed us to develop a short and efficient preparation of (R)-harmicine and (R)-deplancheine alkaloids in high overall yields and ee of 89 and 90%, respectively.
A highly stereoselective synthesis of the indolo[2,3-a]quinolizine ring system and application to natural product synthesis
Allin, Steven M.,Thomas, Christopher I.,Allard, James E.,Doyle, Kevin,Elsegood, Mark R. J.
, p. 4179 - 4186 (2007/10/03)
We present a facile and highly stereoselective approach to the indolo[2,3-a]quinolizine ring system from a readily available, non-racemic chiral template. We demonstrate the potential for application of this methodology to natural product synthesis throug
An asymmetric synthesis of both enantiomers of the indole alkaloid deplancheine
Allin, Steven M.,Thomas, Christopher I.,Doyle, Kevin,Elsegood, Mark R. J.
, p. 357 - 359 (2007/10/03)
(Chemical Equation Presented). We report a novel, facile and asymmetric approach to both enantiomers of the indole alkaloid deplancheine from a readily available, nonracemic chiral template. The natural product and its antipode are isolated with >95% ee.
