74598-75-7

Upstream product

• 100-18-5 1,4-bis(1-methylethyl)benzene 
• 4885-02-3 Dichloromethyl methyl ether 
• 98-82-8 Isopropylbenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 59424-92-9 2,2,2-Trichloro-1-(2,5-diisopropyl-phenyl)-ethanol 
• 945971-89-1 2,5-di-isopropylbenzyl alcohol 
• 1558011-07-6 1-(2,5-diisopropylphenyl)ethanol 
• 1558011-11-2 C₃₄H₄₁ClNPPd 
• 1558011-10-1 (±)-trans-dichlorobis[1-(2,5-diisopropylphenyl)-N-methylethanamine]palladium(II) 
• 1558011-09-8 1-(2,5-diisopropylphenyl)-N,N-dimethylethanamine 
• 1558011-08-7 2-(1-bromoethyl)-1,4-diisopropylbenzene 
• 59424-70-3 1,4-Diisopropyl-2-[2,2,2-trichloro-1-(4-methoxy-phenyl)-ethyl]-benzene 
• 177166-37-9 2,5-Diisopropylphenyl-tris(trimethylsilyl)methanol 

Relevant academic research and scientific papers

BENZODIAZEPINONE COMPOUNDS AND METHODS OF TREATMENT USING SAME

The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.

BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS

The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.

Paracyclophanes. Part 58 [1]. On the use of the stilbene-phenanthrene photocyclization in [2.2]paracyclophane chemistry

The application of the stilbene→phenanthrene photocyclization to [2.2]paracyclophane chemistry has been investigated. For the model system 4-styryl[2.2]paracyclophane (2) to [2.2]phenanthrenoparacyclophane (3) the reaction allows the introduction of alkyl substituants in the 6-, 7-, 8- and 9-position of the phenanthrene moiety. However, when the substituent in the 9-position (bay area of phenanthrene nucleus) becomes too large, viz. tert-butyl, no ring closure is observed anymore. The side products of the process (ring cleavage products of the cyclophane core such as 9 and 10) have been characterized for the first time. Extension of the condensed deck is possible leading to PAH-phanes as demonstrated by the preparation of the chrysenophanes 45 and 60; the cyclization to novel helicenophanes such as 50 also takes place without difficulties. In the case of 1,2-di(4-[2.2] paracyclophanyl)ethene (63) the triply-layered hydrocarbon 65 is produced on irradiation in small amounts.

Formylation and Acylation Reactions Catalysed by Trifluoromethanesulphonic Acid

Regioselective formylation of toluene, m- and p-xylene, and mesitylene has been achieved by carbonylation in trifluoromethanesulphonic acid at CO pressures of 90-125 atm.In the case of cumene, the formylation reaction is in competition with disproportionation to form di- and tri-isopropylbenzenes, leading to a complex product mixture.Slow addition of cyclohexene or cyclopentene to a mixture of benzene and CF3SO3H under a high CO pressure affords 4-cyclohexylbenzaldehyde and 4-cyclopentylbenzaldehyde in 34percent and 33percent yieds, respectively, while 2-methylbut-1-ene gives 2,2,3-trimethylindanone (39percent) under similar conditions.When cyclohexene is mixed with the acid under carbon monoxide (120 atm) before addition of benzene the major products are cyclohexyl phenyl ketone and cyclohexenyl cyclohexyl ketones.