74603-92-2Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF (S)-2-AMINO-5-CYCLOPROPYL-4,4-DIFLUOROPENTANOIC ACID AND ALKYL ESTERS AND ACID SALTS THEREOF
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Page/Page column 18-19, (2011/04/13)
The present invention relates to a process for the preparation of alkyl esters of (S) 2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)-N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-t
The Bronsted Acid-Catalyzed Direct Aza-Darzens Synthesis of N-Alkyl cis-Aziridines
Williams, Amie L.,Johnston, Jeffrey N.
, p. 1612 - 1613 (2007/10/03)
A mild protocol for the synthesis of cis-aziridines is described that employs a catalytic amount of Bronsted acid. Despite the potential for diazo compound decomposition via alkylation or homocoupling upon exposure to a proton source, these pathways are slow relative to [2 + 1] annulation in the presence of a Schiff base, leading to aziridine product. The process uses no metals or reagents that must be removed chromatographically, exhibits rapid turnover rates, and produces only atomic nitrogen as a coproduct. High levels of relative stereocontrol are also possible when forming the Schiff base from a chiral nonracemic aldehyde. Copyright
