74617-55-3Relevant articles and documents
Synthesis, structural, magnetic, DFT calculations and CShM studies of three new pentanuclear Mn(ii) clusters
Mandal,Roy,Konar,Jana,Das,Ray,Gupta,Saha,El Fallah,Tercero,Butcher,Chatterjee,Kar
, p. 413 - 423 (2012)
The ditopic ligand PyPzOAPz (N-[(Z)-amino(pyrazin-2-yl)methylidene]-5- methyl-1-(pyridin-2-yl)-1H-pyrazole-3-carbohydrazonic acid) was synthesized by in situ condensation of methyl imino pyrazine-2-carboxylate with 5-methyl-1-(2-pyridyl) pyrazole-3-carbohydrazide. In this work we have also used two of our earlier ligands PzCAP (5-methyl-N-[(1E)-1-(pyridin-2-yl)ethylidene]- 1H-pyrazole-3-carbohydrazonic acid) (Dalton Trans., 2009, 8215) and PzOAP (N-[(Z)-amino(pyridin-2-yl)methylidene]-5-methyl-1H-pyrazole-3-carbohydrazonic acid) (Dalton Trans., 2007, 1229). These ligands PzCAP, PzOAP and PyPzOAPz were made to react with Mn(ClO4)2.6H2O to produce three pentanuclear Mn(ii) clusters [Mn5(PzCAP)6](ClO 4)4 (1), [Mn5(PzOAP)6](ClO 4)4 (2) and [Mn5(PyPzOAPz)6] (ClO4)4 (3). These complexes have been characterized by X-ray structural analyses and variable temperature magnetic susceptibility measurements. All complexes have a pentanuclear core with trigonal bipyramidal arrangement of Mn(ii) atoms, where, the axial metal centers have a N 3O3 chromophore and the equatorial centers have N 4O2 with an octahedral arrangement. These Mn 5(ii) clusters 1, 2 and 3 show the presence of antiferromagnetic coupling within the pentanuclear manganese(ii) core (J = -2.95, -3.19 and -3.00 cm-1 respectively). Density functional theory calculations and continuous shape measurement (CShM) studies have been performed on these complexes to provide a qualitative theoretical interpretation of the antiferromagnetic behaviour shown by them. The pentanuclear Mn(ii) cluster (1) on reaction with Cu(NO3)2.6H2O in 1:1 mole proportion in CH3OH:H2O (60:40) forms a homoleptic [2 × 2] tetranuclear Cu4(ii) grid [Cu4(PzCAP) 4(NO3)2](NO3)2.8H 2O (4). The same Cu4(ii) grid is also obtained from a direct reaction between the ditopic ligand PzCAP with Cu(NO3) 2.6H2O in 1:1 mole proportion. This conversion of a cluster to a grid is a novel observation.
One-pot method for synthetizing 3,5-disubstituted-1,2,4-triazole compounds
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Paragraph 0026-0028, (2017/01/23)
The invention provides a one-pot method for preparing 3,5-disubstituted-1,2,4-triazole compounds shown in the general formula (I). In the general formula, at least one of X1, X2, X3 and X4 is selected from a nitrogen atom, and the others are selected from -CH; at least one of X5, X6, X7 and X8 is selected from a nitrogen atom, and the others are selected from -CH. A cascade reaction is adopted, all intermediate products are not separated or purified, that is, aromatic nitrile serving as a raw material has an addition reaction with methoxyl negative ions, and target compounds are synthetized directly under a solvothermal condition. Synthesis steps are simple, after-treatment is convenient, and large-scale production is easy to realize.
Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides
Gobis, Katarzyna,Foks, Henryk,Slawinski, Jaroslaw,Sikorski, Artur,Trzybinski, Damian,Augustynowicz-Kopec, Ewa,Napiorkowska, Agnieszka,Bojanowski, Krzysztof
, p. 647 - 658 (2013/07/26)
A series of novel heterocyclic sulfonyl-carboximidamides were synthesized in satisfactory yields via condensation of heterocyclic methyl carbimidates with 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide. New structures were confirmed by IR and NMR spectra as well as elemental analyses. X-ray crystallography of two derivatives was performed. The single-crystal structures confirmed the presence of a primary amine group in the amidine moiety. All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92-13 μM.