7462-45-5

Basic information

• Product Name: (2S,3S)-2-Dibenzylamino-3-hydroxy-butyric acid
• CAS NO: 7462-45-5
• Molecular Weight: 299.37
• Mol File: 7462-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S)-2-Dibenzylamino-3-hydroxy-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-2-Dibenzylamino-3-hydroxy-butyric acid(7462-45-5)
• EPA Substance Registry System: (2S,3S)-2-Dibenzylamino-3-hydroxy-butyric acid(7462-45-5)

Safety Data

• Hazardous Substances Data: 7462-45-5(Hazardous Substances Data)

Upstream product

• 80-68-2 DL-threonine 
• 100-44-7 benzyl chloride 
• 94226-78-5 2-Dibenzylamino-3-oxo-butyric acid tert-butyl ester 
• 94226-77-4 2-Dibenzylamino-3-oxo-butyric acid methyl ester 
• 94226-55-8 (dibenzylamino)acetic acid methyl ester 
• 17360-47-3 N,N-dibenzylglycine 
• 118965-95-0 (Z)-tert-butoxy-2-(dibenzylamino)-1-(trimethylsiloxy)ethylene 
• 94226-56-9 tert-butyl 2-(dibenzylamino)ethanoate 

Downstream Products

• 80-68-2 DL-threonine 
• 72-19-5 L-threonine 

Relevant articles and documents

DIBENZYLAMINOACETATES AS USEFUL SYNTHETIC EQUIVALENTS OF GLYCINE IN THEi SYNTHESIS OF α-AMINO-β-HYDROXYACIDS

The stereochemical course of three new simple methodologies for the preparation of α-amino-β-hydroxyacids starting from dibenzylaminoacetates as synthetic equivalents of glycine is described.While the aldol-type condensation via lithium enolates gave results highly dependent on the aldehyde employed, producing in some cases diastereoselectivities up to 5:1 for the anti isomers, the acid-catalysed aldol condensation of silyl ketene acetals yielded predominantly syn adducts with selectivities from 5:1 to 32:1.Finally the acylation-reduction procedure gave the best results in terms of yields and stereoselectivities, affording syn isomers with excellent induction ( 13:1).