Welcome to LookChem.com Sign In|Join Free

CAS

  • or

80-68-2

Post Buying Request

80-68-2 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • Provide high quality research reagent DL-Theronine CAS 80-68-2

    Cas No: 80-68-2

  • USD $ 5.5-5.5 / Metric Ton

  • 1 Metric Ton

  • 1000 Metric Ton/Day

  • KAISA GROUP INC
  • Contact Supplier

80-68-2 Usage

Chemical properties

Because of the 2 asymmetric carbon atoms contained in the threonine molecule there are D-threonine, L-threonine, D-doxylthreonine and L-doxylthreonine, four kinds of optical isomers, of which the amino acids constituting the protein is L-threonine while the other three optical isomers can not be used. DL-threonine appears as white crystalline or crystalline powder, being odorless with slightly sweet taste. The melting point is about 245 ° C (decomposition). It can be dissolved in water (20.1g/100mL, 25 ° C), being insoluble in organic solvents such as ethanol. It has stable chemical property. Rats-intraperitoneally injection-LD50: 5.355 g/kg (type D). L-threonine [72-19-5] has a melting point of about 256 ℃ (decomposition) with the physiological effect of the DL-type being 2 times of that of the DL-type. Rats subjecting to intraperitoneal injection has a LD50 of 3.094g/kg. The rest is the same as the DL type.

Uses

Different sources of media describe the Uses of 80-68-2 differently. You can refer to the following data:
1. DL-Threonine is as an additive to animal feed. They are also used to chelate metal cations in order to improve the absorption of minerals from supplements, which may be required to improve the health or production of animals. This chelating ability is also used in fertilizers for agriculture.DL-Threonine is an essential, non-protein amino acid naturally occurring in the human body and it is involved in many biological processes. DL-threonine takes part in the conversion of glycogen into the glucose pathway, supports muscle tissue maintenance and growth, and plays a key role in regulating levels of other amino acids.L-threonine? is essential amino acids with the physiological effect of DL-threonine being half of that of the L-threonine. Upon its lack, people is easily susceptible to loss of appetite and fatty liver embolism. Threonine can not be de novo synthesized inside the higher animals body and must be supplied externally. The cereal protein, in addition to should being provided of L-lysine, should also be supplied with L-threonine. This is due to that although there is a high content of L-threonine, but the combination of threonine and peptide in the protein is difficult to be hydrolyzed and is not easily digested and absorbed. As a nutritional supplement, in order to play the best use of fruit, it can be co-used with glycine in the rice, co-used with glycine and valine in wheat flour, and co-used with glycine and methionine in the barley, oats as well as co-used with glycine and tryptophan in corn. Co-heating with hot grapes can easily produce empyreumatique and chocolate flavor with aromatherapy role. It can also be used for separation to obtain L-threonine and further for the preparation of amino acid infusion and integrated amino acid preparations.
2. DL-Threonine is used as a polar essential amino acid. It serves as a precursor of glycine as well as used in the biosynthesis of proteins. Further, it is used for biochemical research. In addition to this, it is used as a nutrition enhancer.

Content analysis

It is the same as the content analysis method of "DL-alanine". Every mL of 0.1mol/L perchloric acid solution is equivalent to 11.91 mg of DL-threonine (C4H9NO3).

Toxicity

L-type: LD50: 26mmol/kg (rat, intraperitoneal injection); D-type: LD50 45mmol/kg (rat, intraperitoneal injection). It can be safely applied to food products (FDA, §172.320, 2000).

Description

Threonine (abbreviated as Thr or T) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(OH)CH3. Its codons are ACU, ACA, ACC, and ACG. This essential amino acid is classified as polar. Together with serine, threonine is one of two proteinogenic amino acids bearing an alcohol group (tyrosine is not an alcohol but a phenol, since its hydroxyl group is bonded directly to an aromatic ring, giving it different acid/base and oxidative properties). It is also one of two common amino acids that bear a chiral side chain, along with isoleucine.The threonine residue is susceptible to numerous posttr anslational modifications. The hydroxy side-chain can undergo Olinked glycosylation. In addition, threonine residues undergo phospho rylation through the action of a threonine kinase. In its phosphorylated form, it can be referred to as phospho threonine.

Chemical Properties

White crystalline powder

Occurrence

Foods high in threonine include cottage cheese, poultry, fish, meat, lentils, Black turtle bean and Sesame seeds. Racemic threonine can be prepared from crotonic acid by alphafunctionalization using mercury (II) acetate.

History

Threonine was discovered as the last of the 20 common proteinogenic amino acids in the 1930s by William Cumming Rose.

Brand name

L -Threonine is JAN.

Biosynthesis

As an essential amino acid, threonine is not synthesized in humans, hence we must ingest threonine in the form of threoninecontaining proteins. In plants and microorganisms, threonine is synthesized from aspartic acid via α-aspartyl-semialdehyde and homoserine. Homoserine undergoes O-phosphorylation; this phosphate ester undergoes hydrolysis concomitant with relocation of the OH group. Enzymes involved in a typical biosynthesis of threonine include : aspartokinase β-aspartate semialdehyde dehydrogenase homoserine dehydrogenase homoserine kinase threonine synthase.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 1031, 1991 DOI: 10.1016/S0040-4039(00)74479-0The Journal of Organic Chemistry, 63, p. 3499, 1998 DOI: 10.1021/jo9722717

Metabolism

Threonine is metabolized in two ways: It is converted to pyruvate via threonine dehydrogenase. An intermediate in this pathway can undergo thiolysis with CoA to produce acetyl-CoA and glycine. In humans, it is converted to α-ketobutyrate in a less common pathway via the enzyme serine dehydratase, and thereby enters the pathway leading to succinyl-CoA..

Stereoisomerism

Threonine is one of two proteinogenic amino acids with two chiral centers. Threonine can exist in four possible stereo isomers with the following configurations: (2S,3R), (2R,3S), (2S,3S) and (2R,3R). However, the name L-threonine is used for one single diastereomer, (2S,3R)-2-amino-3-hydroxybutanoic acid. The second stereoisomer (2S,3S), which is rarely present in nature, is called L-allo-threonine. The two stereo isomers (2R,3S)- and (2R,3R)-2-amino-3-hydroxy butanoic acid are only of minor importance.

Check Digit Verification of cas no

The CAS Registry Mumber 80-68-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 80-68:
(4*8)+(3*0)+(2*6)+(1*8)=52
52 % 10 = 2
So 80-68-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)

80-68-2 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (T0229)  DL-Threonine  >98.0%(T)

  • 80-68-2

  • 25g

  • 285.00CNY

  • Detail
  • TCI America

  • (T3105)  DL-Threonine (contains DL-Allothreonine)  >97.0%(T)

  • 80-68-2

  • 25g

  • 350.00CNY

  • Detail
  • TCI America

  • (T3105)  DL-Threonine (contains DL-Allothreonine)  >97.0%(T)

  • 80-68-2

  • 100g

  • 1,250.00CNY

  • Detail
  • Alfa Aesar

  • (A10606)  DL-Threonine, 99%   

  • 80-68-2

  • 25g

  • 237.0CNY

  • Detail
  • Alfa Aesar

  • (A10606)  DL-Threonine, 99%   

  • 80-68-2

  • 100g

  • 728.0CNY

  • Detail
  • Alfa Aesar

  • (A10606)  DL-Threonine, 99%   

  • 80-68-2

  • 500g

  • 3241.0CNY

  • Detail

80-68-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name DL-Threonine

1.2 Other means of identification

Product number -
Other names DL-Theronine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80-68-2 SDS

80-68-2Relevant articles and documents

Preparation and purification method of amino acid compound

-

Paragraph 0066; 0067, (2018/06/21)

The invention relates to the field of industrial organic synthesis, in particular to a preparation and purification method of an amino acid compound. The method comprises the following steps that (1)alpha-amino nitrile compounds or hydantoin compounds or mixtures thereof are heated to react to obtain alpha-amino acid salt under the condition that volatile alkali and a suitable solvent exist; (2)after the alpha-amino acid salt obtained in step (1) is distilled, the alpha-amino acid salt is recrystallized in an organic solvent to obtain the alpha-amino acid compound. According to the method, reaction conditions are mild, materials can be recycled, and introduction of metal ions and use of ammonium carbonate salt are avoided, so that post-treatment is simple and no waste salt is generated.

Ohmyungsamycins A and B: Cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island

Um, Soohyun,Choi, Tae Joon,Kim, Heegyu,Kim, Byung Yong,Kim, Seong-Hwan,Lee, Sang Kook,Oh, Ki-Bong,Shin, Jongheon,Oh, Dong-Chan

, p. 12321 - 12329 (2014/01/17)

Ohmyungsamycins A and B (1 and 2), which are new cyclic peptides, were isolated from a marine bacterial strain belonging to the Streptomyces genus collected from a sand beach on Jeju, a volcanic island in the Republic of Korea. Based on the interpretation of the NMR, UV, and IR spectroscopic and MS data, the planar structures of 1 and 2 were elucidated as cyclic depsipeptides bearing unusual amino acid units, including N-methyl-4-methoxytrytophan, β-hydroxyphenylalanine, and N,N-dimethylvaline. The absolute configurations of the α-carbons of the amino acid residues were determined using the advanced Marfey's method. The configurations of the additional stereogenic centers at the β-carbons of the threonine, N-methylthreonine, and β-hydroxyphenylalanine units were assigned by GITC (2,3,4,6-tetra-O-acetyl- β-d-glucopyranosyl isothiocyanate) derivatization and the modified Mosher's method. We have developed a new method utilizing PGME (phenylglycine methyl ester) derivatization coupled with chromatographic analysis to determine the absolute configuration of N,N-dimethylvaline. Our first successful establishment of the absolute configuration of N,N-dimethylvaline using PGME will provide a general and convenient analytical method for determining the absolute configurations of amino acids with fully substituted amine groups. Ohmyungsamycins A and B showed significant inhibitory activities against diverse cancer cells as well as antibacterial effects.

Compositions and Methods for Binding Lysophosphatidic Acid

-

, (2009/06/27)

Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 80-68-2