7463-34-5

Upstream product

• 615-83-8 2-bromo-pentanoic acid ethyl ester 
• 2531-82-0 ethyl 2-nitropentanoate 
• 109-95-5 ethyl nitrite 
• 64-17-5 ethanol 
• 24317-96-2 2-propyl-3-oxo-3-phenylpropionic acid ethyl ester 
• 141-52-6 sodium ethanolate 
• 1540-28-9 ethyl 2-propylacetoacetate 
• 22623-98-9 α-Nitro-β-aethylacrylsaeureaethylester 
• 86294-59-9 (E)-1-Ethoxy-1-(trimethylsiloxy)penten 

Downstream Products

• 13893-43-1 ethyl 2-aminopentanoate 
• 1821-02-9 2-oxopentanoic acid 
• 89598-61-8 5-Hydroxy-3-mercapto-6-propyl-1,2,4-triazin 

Relevant academic research and scientific papers

Titanium(IV) enolates of 2-nitrocarboxylic esters and their oxidative chlorinationa convenient route to α-chloro-α-nitrocarboxylates

A new method for the synthesis of 2-chloro-2-nitrocarboxylic esters from 2-nitrocarboxylates is described. The procedure consists of the oxidative chlorination of titanium(IV) enolates of 2-nitro esters in the presence of ammonium nitrate. Esters of 2-chloro-2-nitrocarboxylic acids are formed in very good to quantitative yields. Application of this method for the chlorination of α,α′-dinitrodicarboxylates leads to α,α′- dichloro-α,α′-dinitrocarboxylic esters with high meso-diastereoselectivity. The absence of ammonium nitrate from the reaction mixture affects the reduction of nitro groups and leads to partial transformation of 2-nitrocarboxylic esters into 2-(hydroxyimino)carboxylates. Georg Thieme Verlag Stuttgart - New York.

New Synthesis of α-Nitroso Esters and Oximes of α-Keto Esters

Ketene O-alkyl O'-silyl acetals on reaction with nitric oxide or isoamyl nitrite in the presence of titanium(IV) chloride provide either one of α-nitroso esters and oximes of α-keto esters.