7464-18-8

Usage

General Description

1-tetrahydropyran-4-yl-propan-1-one, also known as THPVP, is a chemical compound with the molecular formula C10H18O. It is a synthetic stimulant and a derivative of the cathinone class of compounds. THPVP belongs to a group of substances known as designer drugs, and it has been reported to have stimulating and psychoactive effects. It is often sold and used for recreational purposes, and due to its potential for abuse and addiction, it is considered a controlled substance in many jurisdictions. The exact effects and potential risks of THPVP are not well understood, and it is important to use caution and proper safety measures when dealing with this chemical compound.

InChI:InChI=1/C8H14O2/c1-2-8(9)7-3-5-10-6-4-7/h7H,2-6H2,1H3

Upstream product

• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 999-75-7 ethylzinc iodide 
• 4295-99-2 tetrahydro-2H-pyran-4-carbonitrile 
• 856414-66-9 4-propionyl-4-methoxycarbonyltetrahydropyran 
• 156353-01-4 N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide 
• 925-90-6 ethylmagnesium bromide 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Downstream Products

• 92325-74-1 1-tetrahydropyran-4-yl-propan-1-one-(2,4-dinitro-phenylhydrazone) 

Relevant academic research and scientific papers

INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE

Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

PROCESSES FOR PRODUCING ALKYL 3-(4-TETRAHYDROPYRANYL)-3-OXOPROPIONATE COMPOUND AND 4-ACYLTETRAHYDROPYRAN

The present invention is to provide a process for preparing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropanoate compound represented by the formula (1): wherein R1 and R2 may be the same or different from each other, and represent a group which does not participate in the reaction, and R1 and R2 may be bonded to form a ring, and the ring may contain a hetero atom(s), and R3 represents a hydrocarbon group, which comprises reacting 4-acyltetrahydropyran represented by the formula (2): wherein R1 and R2 have the same meanings as defined above, and a carbonic acid diester represented by the formula (3): wherein R3 has the same meanings as defined above, and two R3s may be bonded to each other to form a ring, in the presence of a base, and a process for preparing 4-acyltetrahydropyran.