74644-00-1

Upstream product

• 186581-53-3 diazomethane 
• 74592-47-5 (3β,3aβ,7aβ)-3a,4,5,7a-Tetrahydro-3,3a,6-trimethyl-3-(4-hydroxybutyl)-2(3H)benzofuranone 
• 932-51-4 2,5-dimethylcyclohexanone 
• 33722-72-4 (3a-cis)-3a,4,5,7a-Tetrahydro-3a,6-dimethyl-2(3H)-benzofuranone 
• 37720-04-0 2,5-Dimethyl-2-(3-propenyl)cyclohexanone 
• 74592-60-2 (1,4-Dimethyl-2-oxo-cyclohexyl)-acetaldehyde 
• 37720-03-9 1,4-Dimethyl-2-oxo-3-cyclohexeneacetic acid 
• 37720-05-1 (1,4-Dimethyl-2-oxo-cyclohexyl)-acetic acid 
• 37720-06-2 Ethyl 1,4-Dimethyl-2-oxo-1-cyclohexaneacetate 
• 37720-07-3 ethyl (1,4-dimethyl-2-oxocyclohex-3-enyl)acetate 
• 74592-37-3 (3-Bromo-1,4-dimethyl-2-oxo-cyclohexyl)-acetic acid ethyl ester 
• 74592-38-4 (3aR,7aR)-3a,6-Dimethyl-3-pent-4-enyl-3a,4,5,7a-tetrahydro-3H-benzofuran-2-one 
• 74592-45-3 (3β,3aβ,7aβ)-3a,4,5,7a-Tetrahydro-3,3a,6-trimethyl-3-(5-pentenyl)-2(3H)-benzofuranone 
• 74592-46-4 4-((3R,3aS,7aS)-3,3a,6-Trimethyl-2-oxo-2,3,3a,4,5,7a-hexahydro-benzofuran-3-yl)-butyraldehyde 

Relevant academic research and scientific papers

Stereoselective Total Synthesis of (+/-)-Trichodiene: Biogenetic Precursor of the Trichothecane Sesquiterpenoids

Two approaches to the total synthesis of (+/-)-trichodiene (1) are reported from cis-fused lactone 10.Sequential alkylation of lactone 10 was observed to be highly stereoselective as established by the construction of diastereomeric lactone esters 12 and