74648-14-9Relevant articles and documents
The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds
Hasinoff, Brian B.,Zhang, Rui,Wu, Xing,Guziec, Lynn J.,Guziec Jr., Frank S.,Marshall, Kyle,Yalowich, Jack C.
, p. 4575 - 4582 (2009)
A series of amide-coupled bisanthrapyrazole derivatives of 7-chloro-2-[2-[(2-hydroxyethyl)methylamino]ethyl]anthra[1,9-cd]pyrazol-6(2H)-one (AP9) were designed using molecular modeling and docking and synthesized in order to develop an anticancer drug tha
Antibody interference with N-Acyl homoserine lactone-mediated bacterial quorum sensing
Kaufmann, Gunnar F.,Sartorio, Rafaella,Lee, Sang-Hyeup,Mee, Jenny M.,Altobell III, Laurence J.,Kujawa, David P.,Jeffries, Emily,Clapham, Bruce,Meijler, Michael M.,Janda, Kim D.
, p. 2802 - 2803 (2007/10/03)
Many bacterial pathogens coordinate their virulence factor expression in a cell density-dependent manner. This population-dependent coordination of gene expression in bacteria has been termed "quorum sensing" (QS). N-Acyl homoserine lactones (AHLs) are us
Synthesis of Bifuctional L-Lysine Derivatives with Phage-inactivating Effect
Kondo, Michio,Shimizu, Yoshikazu,Murata, Akira
, p. 913 - 918 (2007/10/02)
A new type of lysine derivative connected with dicarboxylic acid was synthesized.The acid was coupled with ε-benzyloxycarbonyl-lysine ethyl ester (Lys(Z)-OEt) by conventional methods of peptide synthesis.The removal of the Z-group from the protected compo