74650-80-9Relevant academic research and scientific papers
Amine compound inhibiting SSAO/VAP-1 and application thereof in medicine
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Paragraph 0845; 0846; 0847; 0848, (2019/02/04)
The invention relates to an amine compound for inhibiting semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1) and medicinal application thereof, and further relatesto a pharmaceutical composition containing the compound
Synthesis of 2-Chloro-5-hydroxynicotinonitrile: The Required Intermediate in the Total Synthesis of a Hydroxylated Metabolite of (S)-2-(3-t-Butylamino-2-hydroxypropoxy)-3-cyanopyridine
Ponticello, Gerald S.,Engelhardt, Edward L.,Freedman, Mark B.,Baldwin, John J.
, p. 445 - 448 (2007/10/02)
A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5-amino-2-chloro-3-methylpyridine (3) is described.Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 1
