746591-42-4 Usage
Structure
Furan ring: 5-(4-{4-(3-fluorobenzyloxy)anilino}-6-quinazolinyl)-furan-2-carbaldehyde contains a furan ring.
Benzene ring: It also includes a benzene ring with various substituents.
Substituents:
Furan-2-carbaldehyde group: Present in the compound.
6-Quinazolinyl substituent: Attached to the compound.
3-Fluorobenzyloxy substituent: Also attached to the compound.
Biological Properties
Potential pharmaceutical applications: It has potential uses in drug development.
Further studies required: Specific biological properties need further examination.
Chemical Properties
Reactivity: Its reactivity towards other compounds needs investigation.
Functional Groups: Contains aldehyde, furan, anilino, quinazolinyl, and fluorobenzyloxy groups.
Medical Applications
Drug Development: May be utilized in developing new drugs for various medical conditions.
Research Needs
Understanding effects: Further research is necessary to comprehend its potential effects and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 746591-42-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,6,5,9 and 1 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 746591-42:
(8*7)+(7*4)+(6*6)+(5*5)+(4*9)+(3*1)+(2*4)+(1*2)=194
194 % 10 = 4
So 746591-42-4 is a valid CAS Registry Number.
746591-42-4Relevant academic research and scientific papers
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series
Petrov, Kimberly G.,Zhang, Yue-Mei,Carter, Malcolm,Cockerill, G. Stuart,Dickerson, Scott,Gauthier, Cassandra A.,Guo, Yu,Mook Jr., Robert A.,Rusnak, David W.,Walker, Ann L.,Wood, Edgar R.,Lackey, Karen E.
, p. 4686 - 4691 (2007/10/03)
Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity. Changes made to the 6-furanyl group had little impact on the enzyme activity, but appeared to dramatically affect the cellular efficacy. The discovery of lapatinib emerged from this work.
