746641-80-5Relevant academic research and scientific papers
Catalytic route to the synthesis of optically active β,β- difluoroglutamic acid and β,β-difluoroproline derivatives
Suzuki, Atsushi,Mae, Masayuki,Amii, Hideki,Uneyama, Kenji
, p. 5132 - 5134 (2004)
β,β-Difluorinated amino acid derivatives were synthesized via Mg(0)-promoted defluorination of α-trifluoromethyl iminoester. Bromination of the difluoroenamine afforded the bromodifluoromethyl iminoester in good yield. Pd-catalyzed asymmetric hydrogenation of the bromodifluoromethyl iminoester and the subsequent transformations provided optically active β,α-difluoroglutamic acid and β,β-difluoroproline derivatives.
