74671-08-2Relevant academic research and scientific papers
Inhibition of Mammalian Folylpolyglutamate Synthetase and Human Dihydrofolate Reductase by 5,8-Dideaza Analogues of Folic Acid and Aminopterin Bearing a Terminal L-Ornithine
Patil, Shirish A.,Shane, Barry,Freisheim, James H.,Singh, Shyam K.,Hynes, John B.
, p. 1559 - 1565 (2007/10/02)
Six new 5,8-dideaza analogues of folic acid and aminopterin containing a terminal L-ornithine residue were prepared by using multistep synthetic sequences.Each was evaluated as an inhibitor of hog liver folylpolyglutamate synthetase and human dihydrofolat
