7470-09-9

Usage

Uses

Used in Pharmaceutical Industry:
(1Z)-1-[(hydroxyamino)methylidene]naphthalen-2-one is used as a key intermediate in the synthesis of warfarin, an anticoagulant medication. It plays a crucial role in the development of this medication, which is used to prevent and treat blood clots in various medical conditions.
Used in Organic Chemistry Research:
(1Z)-1-[(hydroxyamino)methylidene]naphthalen-2-one is used as a versatile building block in the synthesis of many other organic compounds. Its hydroxyamino group allows for various chemical reactions, making it an important compound in organic chemistry research for the development of new molecules and materials.

InChI:InChI=1/C11H9NO2/c13-11-6-5-8-3-1-2-4-9(8)10(11)7-12-14/h1-7,12,14H/b10-7-

Upstream product

• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 
• 135-19-3 β-naphthol 

Downstream Products

• 1277186-50-1 C₂₀H₁₃ClN₄OS 
• 1277186-49-8 C₂₀H₁₃BrN₄OS 
• 1277186-48-7 C₂₁H₁₆N₄O₂S 
• 1277186-47-6 C₂₁H₁₆N₄OS 
• 1277186-46-5 C₂₀H₁₄N₄OS 
• 1277186-45-4 C₂₀H₁₃ClN₄OS 
• 1277186-44-3 C₂₀H₁₃BrN₄OS 
• 1277186-43-2 C₂₁H₁₆N₄O₂S 
• 1277186-42-1 C₂₁H₁₆N₄OS 
• 1277186-41-0 C₂₀H₁₄N₄OS 
• 1277186-40-9 C₂₀H₁₃ClN₄O₂ 
• 1277186-39-6 C₂₀H₁₃BrN₄O₂ 
• 1277186-38-5 C₂₁H₁₆N₄O₃ 
• 1277186-37-4 C₂₁H₁₆N₄O₂ 

Relevant academic research and scientific papers

A catalytic regioselective procedure for the synthesis of aryl oximes in the presence of palladium nanoparticles

The synthesis of aryl oximes from aryl aldehyde derivatives was carried out using hydroxylamine hydrochloride and aluminum oxy hydroxide-supported palladium (Pd/AlO(OH) nanoparticles. The procedure is revealed via the regioselective synthesis of oxime der

The local and natural sources in synthetic methods: the practical synthesis of aryl oximes from aryl aldehydes under catalyst-free conditions in mineral water

The synthesis of oximes from aryl aldehydes was prepared using hydroxylamine hydrochloride. The obtained oxime compounds were synthesized at maximum efficiency in mineral water at room temperature. The developed method is economical, practical and environmentally friendly. All of the aldehydes were converted the oxime a method using local sources and useful for industrial applications is introduced in the literature. Graphic abstract: In this study, addition elimination reaction, one of the important reactions of organic chemistry, was carried out using local sources. With this reaction, aryl oximes were obtained from aryl aldehydes in mineral water under catalyst-free conditions.[Figure not available: see fulltext.]

SMALL MOLECULE INHIBITORS OF A PROTEIN COMPLEX

Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.

A preparation method of the compound including wo and using the organic phosphoric acid ester compound detection method

The invention discloses a method for preparing the compounds including wo using the organic phosphoric acid ester compound of the detection method. Including wo compound preparation method is as follows: the reaction substrate is soluble in the reaction solution, then adding hydroxylamine hydrochloride, the mixture is heated reaction; cooling to room temperature, collecting the reaction product on a short silica gel column and purification, eluting with organic solvent, the final product is obtained. The use of the above-mentioned compound detection organic phosphoric acid ester compound include: (1) including wo compound as a probe in a solution to be detected is added in the organophosphorus ester compound, reaction fluorescence detection; (2) in a two-dimensional metal carbide or nitride including wo compound is added, then the load on the glass carbon electrode, soaked in the but in the detection solution, after reaction of the electrochemical detection. The method has fast detection speed, high sensitivity, selectivity, stability is good, the false positive low and the like, it has broad application prospects.

Calculation and experimental measurement of paramagnetic NMR parameters of phenolic oximate Cu(II) complexes

We present a strategy for predicting the unusual 1H and 13C shifts in NMR spectra of paramagnetic bisoximato copper(ii) complexes using DFT. We demonstrate good agreement with experimental measurements, although 1H-13C correlation spectra show that a combined experimental and theoretical approach remains necessary for full assignment.

Solution and Solid State Study on the Recognition of Hydroxyaromatic Aldoximes by Nitrogen Containing Compounds

Structural aspects and fluorescence behaviors of a series of cocrystals of hydroxyaromatic aldoximes, namely, 2(H2NAP)·(4,4′-bipyridine), 2(H2NAP)·(HMTA), H2NAP·caffeine, and (H3OHPA)·theophylline·2H2

A study on fluoride detection and assembly of hydroxyaromatic aldoximes caused by tetrabutylammonium fluoride

Tetrabutylammonium fluoride (TBAF) forms cocrystal H2NAP·TBAF with 2-hydroxynaphthaldoxime (H2NAP) or cocrystal 2(H3OHPA)·TBAF with 2,3-dihydroxyphenylaldoxime (H3OHPA), whereas a similar reaction with 2,4-dihydroxyphenylaldoxime (H3PHPA) forms tetrabutylammonium (TBA) salt TBA(H2.5PHPA)2. Formation of these cocrystals or salts is accompanied by a color change which enables the detection of fluoride ions. Cocrystal H2NAP·TBAF has a layered structure formed by hydrogen bonds between the fluoride ions and parent oxime molecules; the tetrabutylammonium cations are held in between layers of anionic assemblies. On the other hand, cocrystal 2(H3OHPA)·TBAF has a grid-like architecture constructed from hydrogen bonds between the parent oxime molecules and fluoride ions. TBA cations are encapsulated within the grids. It is shown that salt TBA(H2.5PHPA)2 forms anionic assemblies to encapsulate tetrabutylammonium cations which are devoid of fluoride ions. By interactions of the tetrabutylammonium fluoride ions with H3PHPA molecules, an anionic assembly is formed by the sharing of protons, which possesses a grid-like structure. The formation of such an assembly causes color change which enables one to detect fluoride ions by visual means. This journal is

Ferromagnetic exchange in a twisted, oxime-bridged [MnIII 2] dimer

The dimeric complex [MnIII2(Naphth-sao) 2(Naphth-saoH)2(MeOH)2]·4MeOH (1·4MeOH), acts as a simple model complex with which to examine the magneto-structural relationship in polymetallic, oxime-bridged MnIII complexes. Dc magnetic susceptibility studies reveal that ferromagnetic exchange is mediated through the heavily twisted Mn-O-N-Mn moiety (J = +1.24 cm -1) with magnetisation measurements at low temperatures and high fields suggesting significant anisotropy. Simulations of high field, high frequency EPR data reveal a single ion anisotropy, D(MnIII) = -3.94 cm-1. Theoretical studies on simplified model complexes of 1 reveal that calculated values of the exchange coupling and the anisotropy are in excellent agreement with experiment, with the weak ferromagnetism resulting from an accidental orthogonality between the Mn-N-O plane of the first Mn III ion and the Jahn-Teller axis of the second MnIII ion. The Royal Society of Chemistry 2012.

Microwave-assisted efficient one-step synthesis of amides from ketones and benzoxazoles from (2-hydroxyaryl) ketones with acetohydroxamic acid using sulfuric acid as the catalyst

Efficient one-step method for the synthesis of amides directly from ketones and benzoxazoles from (2-hydroxyaryl) ketones by the reaction of acetohydroxamic acid using sulfuric acid as catalyst was described.

A general and convenient route to oxazolyl ligands

A diverse range of chiral and achiral oxazolyl ligands, which have many applications including catalysis and luminescent devices, are synthesized simply in three steps from readily available and inexpensive phenol and amino alcohol starting materials. The method can be applied to ligands with electron-donating/-withdrawing and sterically demanding/undemanding substituents, and can conveniently be scaled up to >25 g of product.