7473-89-4Relevant academic research and scientific papers
1-(Piperidin-4-yl)-2-benzimidazolone compounds and application thereof
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Paragraph 0040; 0042, (2018/03/26)
The invention belongs to the technical field of medicines, and relates to novel 1-(piperidin-4-yl)-2-benzimidazolone compounds, a composition containing the compounds, and a use of the compounds or the composition as human immunodeficiency virus (HIV ) integrase inhibitor. The compounds are used for the antiviral treatment of 2-or-more-years-old HIV-infected persons. The above drugs act on HIV integrase to prevent HIV replication in order to reduce the HIV viral load in blood. The structure of the compounds is represented by general formula (I), and R1 and R2 in the general formula (I) are asdefined in the claims and the description.
Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates
Zheng, Shuai,Primer, David N.,Molander, Gary A.
, p. 7957 - 7961 (2017/11/10)
A nickel/photoredox, dual-catalyzed amidation reaction between alkylsilicate reagents and alkyl/aryl isocyanates is reported. In contrast to the previously reported reductive coupling process, this protocol is characterized by mild reaction conditions and the absence of a stoichiometric reductant. A mechanistic hypothesis involving a nickel-isocyanate adduct is proposed based on literature precedent and further validation by experimental results.
Highly efficient oxidative amidation of aldehydes with amine hydrochloride salts
Yoo, Woo-Jin,Li, Chao-Jun
, p. 13064 - 13065 (2008/02/08)
A mild and efficient copper-catalyzed oxidative amidation of aldehydes was developed using amine HCl salts and tert-butyl hydroperoxide as an oxidant. Copyright
Synthesis of oxazoles and thiazoles using thioimidates
Yokoyama,Menjo,Watanabe,Togo
, p. 1467 - 1470 (2007/10/02)
Several oxazoles and thiazoles were synthesized easily by the reaction of N-(methylthioalkylidene)glycine ethyl ester with diethyl oxalate, acid halides, and thionesters in the presence of base.
