7473-97-4Relevant academic research and scientific papers
Rhodium-catalyzed hydroalkynylation of internal alkynes with silylacetylenes: An alkynylrhodium(I) intermediate generated from the hydroxorhodium(I) complex [Rh(OH)(binap)]2
Nishimura, Takahiro,Guo, Xun-Xiang,Ohnishi, Kohei,Hayashi, Tamio
, p. 2669 - 2672 (2008/09/19)
A highly selective hydroalkynylation of internal alkynes with silylacetylenes giving 1,3-enynes was realized by use of a hydroxorhodium catalyst. As a key intermediate in the catalytic cycle, an alkynylrhodium(I) complex was isolated and investigated for its structure and reactivity.
The synthesis of some 1,1-diphenyl-1-alkoxy-3-alkylamino-2-propanones''' of biological interest
Kourounakis,Chilliard
, p. 825 - 827 (2007/10/02)
The synthesis of 1,1-diphenyl-1-alkoxy-3-alkylamino-2-propanones is reported. For this synthesis the following series of reactions was utilized: 1-phenyl-1-propanone was brominated, the product reacted with benzene (Friedel-Crafts), the 1,1-diphenyl-3-propanone was brominated, then reacted with the appropriate alcohol, the alkoxy derivative was brominated and then reacted with the appropriate amine. The synthesized compounds were tested for analgesic activity. All test compounds showed weak analgesic action, the most active were 1,1-diphenyl-1-ethoxy-3-piperidino-2-propanone and 1,1-diphenyl-1-phenoxy-3-dimethylamino-2-propanone.
