74739-01-8

Upstream product

• 74739-00-7 N'-benzylidene-N,N-diethylurea 
• 109-89-7 diethylamine 
• 30122-00-0 α-chloro-benzylisocyanate 
• 74732-28-8 (1-Isocyanato-1-phenyl)methylphosphonate de diethyle 
• 85522-70-9 α-triphenylphosphonium benzylisocyanate hydrochloride 
• 85522-60-7 N,N-diethyl-N'-trimethylsilyl-N'-α-diethoxyphosphonylbenzylurea 
• 100-52-7 benzaldehyde 
• 634-95-7 N,N-diethylurea 
• 74738-99-1 phenyl <α-(diethylamino)benzyl>carbamate 

Relevant academic research and scientific papers

The role of proton shuttling mechanisms in solvent-free and catalyst-free acetalization reactions of imines

Proton transfer is central to the understanding of chemical processes. More so in addition reactions of the type NuH + E → Nu-EH taking place under solvent-free and catalyst-free conditions. Herein we show that the addition of alcohols or amines (the NuH component) to imine derivatives (the E component), in 1:1 ratio, under solvent-free and catalyst-free conditions, are efficient methods to access N,O and N,N-acetal derivatives. In addition, computational studies reveal that they are catalyzed reactions involving two or even three NuH molecules operating in a cooperative manner as H-bonded NuH?(NuH)n?NuH associates (many body effects) in the transition state through a concerted proton shuttling mechanism (addition of alcohols) or stepwise proton shuttling mechanism (addition of amines), thereby facilitating the key proton transfer step.