74744-22-2Relevant academic research and scientific papers
Yb(OTf)3-promoted ZnCl2-catalyzed conia-ene reaction of linear β-alkynic β-dicarbonyls
Liu, Yu,Song, Ren-Jie,Li, Jin-Heng
experimental part, p. 3663 - 3669 (2010/12/20)
An atom-economical and solvent-free ytterbium(III) triflate promoted, zinc(II) chloride catalyzed Conia-ene method has been developed for the construction of five- to six-membered-ring carbocycles. In the presence of zinc(II) chloride and ytterbium(III) triflate, a variety of linear β-alkynic β-keto esters and -alkynic -diketones were cyclized under neat conditions in moderate to good yields. It is noteworthy that the selectivity toward five- or six-membered-ring carbocycles depends on substituents at the terminal alkynes. Georg Thieme Verlag Stuttgart.
