22414-24-0

Basic information

• Product Name: 2,5-DIMETHOXY-2-METHYL-2,5-DIHYDROFURAN
• Synonyms: 2,5-dihydro-2,5-dimethoxy-2-methyl-fura;2,5-DIMETHOXY-2-METHYL-2,5-DIHYDROFURAN;2,5-DIHYDRO-2,5-DIMETHOXY-2-METHYLFURAN;2,5-Dimethoxy-2-methyl-2,5-dihydrofurane
• CAS NO: 22414-24-0
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• EINECS: 244-972-6
• Product Categories: API intermediates;Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 22414-24-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 46 °C10 mm Hg(lit.)
• Flash Point: 115 °F
• Appearance: /
• Density: 1.019 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.35mmHg at 25°C
• Refractive Index: n20/D 1.429(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,5-DIMETHOXY-2-METHYL-2,5-DIHYDROFURAN(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXY-2-METHYL-2,5-DIHYDROFURAN(22414-24-0)
• EPA Substance Registry System: 2,5-DIMETHOXY-2-METHYL-2,5-DIHYDROFURAN(22414-24-0)

Safety Data

• Statements: 10
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 22414-24-0(Hazardous Substances Data)

Usage

General Description

2,5-Dimethoxy-2-methyl-2,5-dihydrofuran is a chemical compound with the molecular formula C7H12O3. 2,5-DIMETHOXY-2-METHYL-2,5-DIHYDROFURAN belongs to the group of organic chemicals known as furans, which are heterocyclic compounds containing a five-member ring with four carbon atoms and one oxygen atom. The specific structure of this compound includes two methoxy groups (-OCH3), which are oxygenated functional groups attached to the furan ring, and one methyl group (-CH3), which is a hydrocarbon group attached to the ring. Since furans and their derivatives are commonly used in the preparation of important industrial chemicals and pharmaceuticals, 2,5-dimethoxy-2-methyl-2,5-dihydrofuran may have various applications in these areas. However, there is not much specific information available about this particular compound due to its rarity.

InChI:InChI=1/C7H12O3/c1-7(9-3)5-4-6(8-2)10-7/h4-6H,1-3H3

Upstream product

• 534-22-5 2-methylfuran 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 7726-95-6 bromine 
• 16642-33-4 5-methoxy-5-methyl-2,5-dihydro-furan-2-yl hydroperoxide 

Downstream Products

• 108307-87-5 2,5-dimethoxy-5-methyltetrahydrofuran-3-carbaldehyde 
• 636-41-9 2-methyl-1H-pyrrole 
• 50691-32-2 2-methyl-1-phenyl-1H-pyrrole 
• 1632175-10-0 C₂₇H₃₄O₄ 
• 1632174-94-7 C₂₇H₃₄O₄ 
• 74684-44-9 4-Acetyl-3-phenylcyclopent-2-enone 
• 74744-22-2 2-Benzoyl-3-methylcyclopent-2-enone 
• 19522-27-1 Methyl (Z)-4-oxo-2-pentenoate 
• 93135-89-8 2-(5-methyl-2-furyl)-3-keto-L-gulonolactone 3,6-hemiketal 
• 624-45-3 levulinic acid methyl ester 
• 85806-33-3 (1R,2S,3R,4S)-3-Acetyl-bicyclo[2.2.1]hept-5-ene-2-carbaldehyde 
• 59995-47-0 4-Hydroxycyclopent-2-enone 
• 686-21-5 4,5,5-trimethoxy-pentan-2-one 
• 98560-91-9 2,4,5-Trimethoxy-2-methyl-tetrahydro-furan 

Relevant articles and documents

Convenient Syntheses of 4,4-Dimethoxy Esters and Ketones

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NEUROLOGICALLY-ACTIVE COMPOUNDS

The invention provides a compound of the formula (I): wherein R is methyl, ethyl, propyl, isopropyl, butyl, pentyl, neo-pentyl or cyclohexyl, or a salt or solvate thereof. These compounds are selective GABAC receptor antagonists. The invention also provides pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof. The invention also provides methods of enhancing the cognitive activity of an animal and methods of stimulating memory capacity in an animal, comprising the step of administering to the animal an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof.

A Novel Synthesis of rac-5-(Hydroxymethyl)-1-(Tetrahydro-2'-oxofur-3'-yl)-1H-pyrrole-2-carboxaldehyde

A novel six-step synthesis of rac-5-(hydroxymethyl)-1-(tetrahydro-2'-oxofur-3'-yl)-1H-pyrrole-2-carboxaldehyde (rac-1) starting from 2-methylfuran has been developed.The key step is the formation of rac-2-methyl-1-(tetrahydro-2'-oxofur-3'-yl)-1H-pyrrole (rac-7) according to the Clauson-Kaas procedure.Subsequent Vilsmeier formylation, oxidation with lead tetraacetate, and enzymatic hydrolysis led to rac-1.