74745-66-7

Upstream product

• 74745-66-7 (1RS,2SR)-1-phenylpropane-1,2-diamine 
• 14838-15-4 u-2-amino-1-phenylpropan-1-ol 
• 37643-54-2 N-[(4-methylbenzene-1-sulfonyl)(phenyl)methyl]formamide 

Downstream Products

• 74745-66-7 (+)-1cat_F-phenyl-propane-1r_F,2c_F-diamine 
• 74745-66-7 (-)-1cat_F-phenyl-propane-1r_F,2c_F-diamine 

Relevant academic research and scientific papers

Synthesis of 1,2-diamino-1-phenylpropane diastereoisomers from u-N-trifluoroacetyl-2-amino-1-phenylpropan-1-ol

A new simple procedure for the synthesis of diastereomeric 1,2-diamino-1-phenylpropanes starting from u-N-trifluoroacetyl-2-amino-1- phenylpropan-1-ol (N-trifluoroacetylnorephedrine) is described. The trifluoroacetyl protecting group was particularly suit

Copper-catalyzed intermolecular aminoazidation of alkenes

Copper-catalyzed intermolecular aminoazidation of alkenes is described. This novel methodology provides an efficient approach to vicinal amino azides which can easily be transformed into other valuable amine derivatives. The commercially available N-fluorobenzenesulfonimide (NFSI) is used as a nitrogen-radical precursor and TMSN3 as the N3 source. Yields are moderate to excellent, and for internal alkenes aminoazidation occurs with excellent diastereoselectivity.

Aza-Henry reaction of substituted nitroalkanes using α-formamidoaryl sulfones as N-acylimino equivalents

Base-promoted elimination of p-toluenesulfinic acid from N-formamidoaryl sulfones leads to the corresponding N-acylimines that react with primary and secondary nitronate anions giving anti-β-formamido nitroderivatives in good yields and high diastereosele