7477-67-0

Basic information

• Product Name: BISPYRAZOLONE
• Synonyms: BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE);BIS(1-PHENYL-3-METHYL-5-PYRAZOLONE);BISPYRAZOLONE;LABOTEST-BB LT00008461;4,4'-BIS(3-METHYL-1-PHENYL-5-PYRAZOLONE);4,4'-BIS(1-PHENYL-3-METHYL-5-PYRAZOLONE);3,3-DIMETHYL-1,1-DIPHENYL-(4,4-BI-2-PYRAZOLINE)-5,5-DIONE;3,3'-DIMETHYL-1,1'-DIPHENYL-[4,4'-BI-2-PYRAZOLINE]-5,5'-DIONE
• CAS NO: 7477-67-0
• Molecular Formula: C₂₀H₁₈N₄O₂
• Molecular Weight: 346.38
• EINECS: 231-282-5
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Heterocyclic Compounds
• Mol File: 7477-67-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 355 °C
• Boiling Point: 481.12°C (rough estimate)
• Flash Point: 307.6 °C
• Appearance: tan/crystalline
• Density: 1.31
• Refractive Index: 1.6620 (estimate)
• Storage Temp.: Refrigerator
• Solubility: formic acid: 50 mg/mL, clear, yellow
• PKA: 2.15±0.70(Predicted)
• BRN: 572787
• CAS DataBase Reference: BISPYRAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: BISPYRAZOLONE(7477-67-0)
• EPA Substance Registry System: BISPYRAZOLONE(7477-67-0)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 7477-67-0(Hazardous Substances Data)

Usage

Chemical Properties

off-white to cream-yellowish crystalline powder

Uses

Different sources of media describe the Uses of 7477-67-0 differently. You can refer to the following data:
1. Bispyrazolone is an impurity of Edaravone (E335000).
2. It is applied as a reagent for the detection and determination of cyanide. It is also used in an experimental procedure, done in order to remove linamarin in starch from cassava roots, by using plant cell wall-degrading enzymes, xylanase and cellulase. It was also used for spectrophotometric determination and quantization of urea in urine samples. It is also used in assay of cyanogenic compounds and determination of ammonia.

Upstream product

• 7446-08-4 selenium(IV) oxide 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 64-17-5 ethanol 
• 98-95-3 nitrobenzene 
• 89-25-8 edaravone 
• 87085-88-9 5-Methyl-4-nitroso-2-phenyl-2H-pyrazol-3-ol 
• 104525-76-0 4-<-4--2-methylphenylimino>-3-methyl-1-phenyl-2-pyrazolin-5-on 
• 41927-23-5 4-bromo-3-methyl-1-phenylpyrazol-5-one 
• 4719-52-2 4-<phenylimino>-3-methyl-1-phenyl-2-pyrazolin-5-on 
• 4719-41-9 4-Diethylamino-2-methyl-phenylimino-3-methyl-1-phenyl-2-pyrazolin-5-on 
• 117985-07-6 4-Diethylamino-phenylimino-3-methyl-1-phenyl-2-pyrazolin-5-on 

Downstream Products

• 143100-01-0 (Z)-2-(4-Methyl-1,6-diphenyl-1,6-dihydro-furo[2,3-c;5,4-c']dipyrazol-3-yl)-3-{4-[(Z)-2-(4-methyl-1,6-diphenyl-1,6-dihydro-furo[2,3-c;5,4-c']dipyrazol-3-yl)-3-oxo-propenyl]-piperazin-1-yl}-propenal 
• 143099-96-1 3-(1-formyl-2-morpholinylethenyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 
• 143099-97-2 3-(1-formyl-2-piperazinylethenyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 
• 143099-95-0 3-(1-formyl-2-piperidinylethenyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 
• 143100-00-9 3-(1-phenyl-4-pyrazolyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 
• 143099-99-4 3-(4-pyrazolyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 
• 143099-98-3 3-(4-isoxazolyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 
• 124009-63-8 5,5''-dihydroxy-3,3'',5'-trimethyl-1,1'',2'-triphenyl-1H,1''H-[4,4':4',4''-terpyrazol]-3'(2'H)-one 
• 143099-93-8 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 
• 6334-24-3 5,5'-dimethyl-2,2'-diphenyl-2H,2'H-[4,4']bipyrazolylidene-3,3'-dione 
• 143099-91-6 4-<5-chloro-3-(1-formyl-2-dimethylaminoethenyl)-1-phenyl-1H-pyrazol-4-yl>-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one 
• 143099-92-7 3-(1-formyl-2-dimethylaminoethenyl)-4-methyl-1,6-diphenyl-furo<2,3-c:5,4-c'>dipyrazole 

Relevant articles and documents

Preparation method of edaravone related substances

The invention belongs to the field of chemical medicines and particularly relates to a preparation method of an edaravone dimer and an edaravone trimer. The preparation method includes the steps of: adding edaravone to an organic solvent, adding a carbonate and performing a reaction under a high-pressure microwave condition to simultaneously produce the edaravone dimer and edaravone trimer. The preparation method is short in reaction time, employs environment-friendly solvent, has low damage on instrument, greatly reduces reaction time and saves time cost, can simultaneously produce the two edaravone related substances and improves utilization rate of raw materials.

New synthesis of pyrazolo[3,4-b][1,4,5]benzothiadiazepine, -[1,4,5]benzoxadiazepine, -[1,4,5]benzotriazepine and pyrazolo[3,4-b]quinoxaline derivatives

New pyrazolo[3,4-b][1,4,5]benzothiadiazepine and its analogues 3 have been obtained by reaction of 4-nitrosopyrazoles 1 with 2-aminothiophenol 2a and its analogues 2b,c. Under fused conditions, dipyrazolyl derivatives 7a was obtained with a trace amount of quinoxaline 5a. On the other hand, 5b and 7b were obtained in equal amounts. A proposed pathway is presented.

Investigation of Reactions of Pyrazolin-Azomethin Dyes with 2-Pyrazolin-5-one

The pyrazolin-azomethin dyes (3a-d) from 1-phenyl-3-methyl-2-pyrazolin-5-one and various photographic developers have been obtained.The reactions of decolourization of dyes during the 3-methyl-1-phenyl-2-pyrazolin-5-one action was investigated.We ascertained that the substituent changes in the developer had not only the influence on decolourization rate but they also had influence on the order change of the reaction.The various solvents had the same influence on the reaction rate of decolourization.