74772-59-1Relevant academic research and scientific papers
Antitumor, cytotoxic, and antioxidant evaluation of six heterocyclic compounds containing different heterocycle moieties
Abdallah, Suzan Abdelhalim,El-Hashash, Maher Abdel-Aziz,Radwan, Tasneem Mokhtar,Wasfy, Ashraf Abdel-Hamid Farouk
, (2020/02/04)
Heterocyclic compounds with different heterocycle moieties, namely benzoxazinone, benzimidazole, quinazolinone, and benzofuranone heterocyclic rings, were synthesized, characterized, and evaluated for their anticancer activity against human hepatocellular carcinoma cell line (HepG2) using sulforhodamine B (SRB) and dimethylthiazol-diphenyltetrazolium bromide (MTT) assays. Also, their cytotoxic activities were tested against human epithelioid carcinoma (Hela) cell line in comparison with normal cell, amniotic epithelial (WISH) cell line, as an in vitro toxicity estimation model. The results showed clearly that 2-(2-benzyl-4-oxoquinazolin-3(4H)-yl)acetohydrazide 4 is the most potent antioxidant and anticancer agents. Although, 3-amino-2-benzylquinazolin-4(3H)-one 5 is less potent anticancer agent against Hela but it is more safe against normal cell (WISH).
Synthesis of poly(pyridazinoquinazolones)
Ponomarev,Razorenov,Petrovskii
, p. 2376 - 2384 (2014/05/06)
A model reaction of 2-alkyl-3-aminoquinazolones with α-dicarbonyl compounds benzil and its 4,4′-derivatives, acenaphthenequinone and isatin was studied for the first time. The reaction proceeded in pentafluorophenol and led to the formation of new heterocyclic systems. This approach was used in the synthesis of new thermostable polyheteroarylenes with fluorescent properties, viz., poly(pyridazinoquinazolones).
A New Synthesis of 2-Aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones
Reddy, Ch. K.,Reddy, P. S. N.,Ratnam, C. V.
, p. 902 - 904 (2007/10/02)
The reaction of 2-aryl-3,1-benzoxazine-4-ones (1) and hydrazine hydrate in refluxing xylene yields 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones in 55-74percent yield.In basic conditions this reaction, however, gives 2-aryl-3-aminoquinazolin-4(3H)-one
