6048-20-0

Basic information

• Product Name: 4-nitrobenzoyl cyanide
• Synonyms: 4-nitrobenzoyl cyanide
• CAS NO: 6048-20-0
• Molecular Weight: 176.131
• Mol File: 6048-20-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-nitrobenzoyl cyanide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrobenzoyl cyanide(6048-20-0)
• EPA Substance Registry System: 4-nitrobenzoyl cyanide(6048-20-0)

Safety Data

• Hazardous Substances Data: 6048-20-0(Hazardous Substances Data)

Upstream product

• 825-52-5 2-(hydroxyimino)-2-phenylacetonitrile 
• 51920-53-7 p-nitrobenzoyl cyanide oxime 
• 114263-87-5 bromo-nitro-phenyl-acetonitrile 
• 71189-80-5 2-(4-nitrophenyl)-2-[(trimethylsilyl)oxy]acetonitrile 
• 3041-40-5 2-phenylmalononitrile 
• 1904-60-5 3-amino-2-phenylquinazolin-4(3H)-one 
• 99-81-0 4-Nitrophenacyl bromide 
• 7077-65-8 2-(4-nitrophenyl)malononitrile 
• 74772-59-1 2-benzyl-3-amino-4-oxo-3,4-dihydroquinazoline 
• 1704-56-9 silver phenylcyanomethylenenitronate 
• 76-83-5 trityl chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 121986-07-0 p-nitromandelonitrile 
• 74-90-8 hydrogen cyanide 

Downstream Products

• 134304-63-5 (Z)-1,2-Dihydro-1-(4'-nitrobenzoylmethylene)isoquinoline 
• 38968-78-4 2-(4'-nitro)benzoylcyclohexanone 
• 5407-25-0 2-amino-2-(4-nitrophenyl)acetic acid 
• 125173-90-2 7-<4-phenyl>heptanoic acid 
• 66147-99-7 7-(4-nitrophenyl)heptanoic acid 
• 1236199-57-7 C₁₇H₂₆Cl₂N₂O₂ 
• 1187162-56-6 1-(4-nitrophenyl)-2,5,5-triphenylpenta-2,3,4-trien-1-one 
• 134304-64-6 (Z)-5,6-Dihydro-6-(4'-nitrobenzoylmethylene)phenanthridine 
• 134304-61-3 (Z)-1,2-Dihydro-2-(4'-nitrobenzoylmethylene)quinoline 
• 81316-40-7 trans-2,3-bis(carbomethoxy)-p,p'-dinitrostilbene oxide 
• 57699-31-7 cis-2,3-bis(carbomethoxy)-p,p'-dinitrostilbene oxide 
• 57699-27-1 methyl p-nitrophenylglyoxylate 
• 88875-53-0 1-benzyl-5-benzoylimino-4-hydroxy-3-methyl-4-(4-nitrophenyl)-2-phenyl-4,5-dihydropyrrole 
• 88875-55-2 5-acetylimino-1-benzyl-4-hydroxy-4-(4-nitrophenyl)-2-phenyl-4,5-dihydropyrrol 

Relevant articles and documents

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).

HYDROXAMIC ACID DERIVATIVES

The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.

Reinterpretation of curved hammett plots in reaction of nucleophiles with aryl benzoates: Change in rate-determining step or mechanism versus ground-state stabilization

A kinetic study is reported for the reaction of the anionic nucleophiles OH-, CN-, and N3- with aryl benzoates containing substituents on the benzoyl as well as the aryloxy moiety, in 80 mol % H2O-20 mol % dimethyl sulfoxide at 25.0 °C. Hammett log k vs σ plots for these systems are consistently nonlinear. However, a possible traditional explanation in terms of a mechanism involving a tetrahedral intermediate with curvature resulting from a change in rate-determining step is considered but rejected. The proposed explanation involves ground-state stabilization through resonance interaction between the benzoyl substituent and the electrophilic carbonyl center in the two-stage mechanism. Accordingly, the data are nicely accommodated on the basis of the Yukawa-Tsuno equation, which gives linear plots for all three nuceophiles. Literature reports of the mechanism of acyl transfer processes are reconsidered in this light.