74785-90-3Relevant academic research and scientific papers
Stereoselective Synthesis of Substituted Tetrahydropyrans and Isochromans by Cyclization of Phenylseleno Alcohols
Temperini, Andrea,Barattucci, Anna,Bonaccorsi, Paola Maria,Rosati, Ornelio,Minuti, Lucio
, p. 8102 - 8112 (2015)
A selenium-mediated strategy for the stereoselective synthesis of substituted tetrahydropyrans and isochromans has been developed starting from δ-phenylseleno ketones. After enantioselective reduction, the chiral nonracemic phenylseleno alcohols were oxidized to the corresponding selenones, which underwent an effcient 6-exo-tet ring-closure reaction.
